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Secondary malignancies and survival of FCR-treated patients with chronic lymphocytic leukemia in Central Europe
F. Kósa, T. Nečasová, M. Špaček, K. Giannopoulos, I. Hus, T. Jurková, E. Koriťáková, M. Chrápavá, M. Nováčková, I. Katinová, D. Krejčí, A. Jujka, Z. Mátrai, I. Vályi-Nagy, T. Robak, M. Doubek
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Free Medical Journals od 2012
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2012-08-01
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-01
Health & Medicine (ProQuest) od 2012-08-01
Wiley-Blackwell Open Access Titles od 2012
ROAD: Directory of Open Access Scholarly Resources od 2012
Odkazy
PubMed
36205198
DOI
10.1002/cam4.5033
Knihovny.cz E-zdroje
- MeSH
- chronická lymfatická leukemie * farmakoterapie epidemiologie MeSH
- cyklofosfamid terapeutické užití MeSH
- lidé MeSH
- přežití po terapii bez příznaků nemoci MeSH
- protokoly antitumorózní kombinované chemoterapie škodlivé účinky MeSH
- retrospektivní studie MeSH
- rituximab terapeutické užití MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
This is the first large-scale cross-country analysis of patients with chronic lymphocytic leukemia (CLL) aimed to evaluate the incidence, types, and key prognostic factors of secondary malignancies, and to assess the impact on overall survival based on retrospective claims data from three Central European countries. We analyzed 25,814 newly diagnosed CLL patients from Czechia, Hungary, and Poland; 10,312 (39.9%) patients were treated for CLL in study periods between 2004 and 2016. Out of the treated patients, 1986 (19.3%) received the FCR therapy in the first line and 779 (7.6%) received FCR in subsequent lines. We observed that 33.7% of treated patients developed secondary malignancies during the study. Based on country estimates, the probability to develop a secondary malignancy within 4 years since starting the first-line FCR therapy ranged between 28.0% and 36.8%. We found the age at diagnosis, male gender, any malignancy prior to the CLL diagnosis, and the CLL treatment to be the key risk factors for developing secondary malignancies. Specifically, the FCR therapy was a statistically significant (p < 0.001) prognostic factor for risk increase with the hazard ratio between 1.46 and 1.60. Across the three Central European countries, we observed consistent results indicating FCR increased the risk of secondary malignancies in CLL patients. We conclude that secondary malignancies are clearly an undervalued burden for CLL patients, caregivers, and the healthcare system. When evaluating new therapies in regulatory and reimbursement decision making, the factor of secondary malignancies deserves deeper considerations.
Department of Hematology Medical University of Lodz Lodz Poland
Experimental Hematooncology Department Medical University of Lublin Lublin Poland
General University Hospital Prague Prague Czech Republic
Institute of Biostatics and Analysis Ltd Brno Czech Republic
Institute of Biostatistics and Analyses of the Faculty of Medicine Brno Czech Republic
Instutute of Hematology and Transfusion Medicine Warsaw Poland
Janssen Cilag Polska Warsaw Poland
Janssen Global Services LLC Budapest Hungary
University Hospital Brno and CEITEC Masaryk University Brno Czech Republic
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