• Something wrong with this record ?

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V. Micale, M. Di Bartolomeo, S. Di Martino, T. Stark, B. Dell'Osso, F. Drago, C. D'Addario

. 2023 ; 241 (-) : 108279. [pub] 20220911

Language English Country England, Great Britain

Document type Journal Article, Review, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc23004815

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence support that clinical symptomatology cannot be assigned to a single gene mutation, but it involves several genetic factors. More specifically, a tight association between genes and environmental risk factors, which could be mediated by epigenetic mechanisms, may play a role in the development of mental disorders. Several data suggest that epigenetic modifications such as DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA) may modify the severity of the disease and the outcome of the therapy. Indeed, the study of these mechanisms may help to identify patients particularly vulnerable to mental disorders and may have potential utility as biomarkers to facilitate diagnosis and treatment of psychiatric disorders. This article summarizes the most relevant preclinical and human data showing how epigenetic modifications can be central to the therapeutic efficacy of antidepressant and/or antipsychotic agents, as possible predictor of drugs response.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23004815
003      
CZ-PrNML
005      
20230425171733.0
007      
ta
008      
230418s2023 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.pharmthera.2022.108279 $2 doi
035    __
$a (PubMed)36103902
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Micale, Vincenzo $u Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy. Electronic address: vincenzomicale@unict.it
245    10
$a Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets / $c V. Micale, M. Di Bartolomeo, S. Di Martino, T. Stark, B. Dell'Osso, F. Drago, C. D'Addario
520    9_
$a The etiopathogenesis of mental disorders is not fully understood and accumulating evidence support that clinical symptomatology cannot be assigned to a single gene mutation, but it involves several genetic factors. More specifically, a tight association between genes and environmental risk factors, which could be mediated by epigenetic mechanisms, may play a role in the development of mental disorders. Several data suggest that epigenetic modifications such as DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA) may modify the severity of the disease and the outcome of the therapy. Indeed, the study of these mechanisms may help to identify patients particularly vulnerable to mental disorders and may have potential utility as biomarkers to facilitate diagnosis and treatment of psychiatric disorders. This article summarizes the most relevant preclinical and human data showing how epigenetic modifications can be central to the therapeutic efficacy of antidepressant and/or antipsychotic agents, as possible predictor of drugs response.
650    _2
$a lidé $7 D006801
650    12
$a duševní poruchy $x farmakoterapie $x genetika $7 D001523
650    _2
$a epigeneze genetická $7 D044127
650    _2
$a metylace DNA $7 D019175
650    12
$a antipsychotika $x terapeutické užití $7 D014150
650    12
$a mikro RNA $7 D035683
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Di Bartolomeo, Martina $u Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy
700    1_
$a Di Martino, Serena $u Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy
700    1_
$a Stark, Tibor $u Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Scientific Core Unit Neuroimaging, Max Planck Institute of Psychiatry, Munich, Germany
700    1_
$a Dell'Osso, Bernardo $u Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, Milan, Italy, Department of Mental Health, ASST Fatebenefratelli-Sacco, Milan, Italy; "Aldo Ravelli" Research Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan Medical School, Milan, Italy; Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA
700    1_
$a Drago, Filippo $u Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy. Electronic address: fdrago@unict.it
700    1_
$a D'Addario, Claudio $u Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
773    0_
$w MED00006662 $t Pharmacology & therapeutics $x 1879-016X $g Roč. 241, č. - (2023), s. 108279
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36103902 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230418 $b ABA008
991    __
$a 20230425171729 $b ABA008
999    __
$a ok $b bmc $g 1925105 $s 1191024
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 241 $c - $d 108279 $e 20220911 $i 1879-016X $m Pharmacology & therapeutics $n Pharmacol Ther $x MED00006662
LZP    __
$a Pubmed-20230418
Back

Find record

Citation metrics

Archiving options