• Something wrong with this record ?

Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids

E. Szczurowska, E. Szánti-Pintér, N. Chetverikov, A. Randáková, E. Kudová, J. Jakubík

. 2022 ; 24 (1) : . [pub] 20221228

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc23004871

Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23004871
003      
CZ-PrNML
005      
20230425171753.0
007      
ta
008      
230418s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms24010507 $2 doi
035    __
$a (PubMed)36613951
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Szczurowska, Ewa $u Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech Republic
245    10
$a Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids / $c E. Szczurowska, E. Szánti-Pintér, N. Chetverikov, A. Randáková, E. Kudová, J. Jakubík
520    9_
$a Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.
650    12
$a neurosteroidy $x farmakologie $7 D000081227
650    _2
$a centrální nervový systém $7 D002490
650    _2
$a steroidy $x farmakologie $x fyziologie $7 D013256
650    _2
$a hormony $7 D006728
650    _2
$a receptory muskarinové $7 D011976
650    _2
$a cholinergní látky $7 D018678
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Szánti-Pintér, Eszter $u Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech Republic
700    1_
$a Chetverikov, Nikolai $u Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
700    1_
$a Randáková, Alena $u Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
700    1_
$a Kudová, Eva $u Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo Náměstí 2, Prague 6, 166 10 Prague, Czech Republic $1 https://orcid.org/0000000171315948
700    1_
$a Jakubík, Jan $u Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic $1 https://orcid.org/0000000217371487 $7 xx0281420
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 24, č. 1 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36613951 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230418 $b ABA008
991    __
$a 20230425171750 $b ABA008
999    __
$a ok $b bmc $g 1925143 $s 1191080
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 24 $c 1 $e 20221228 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
LZP    __
$a Pubmed-20230418

Find record

Citation metrics

Archiving options