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Acute Severe Heart Failure Reduces Heart Rate Variability: An Experimental Study in a Porcine Model
J. Naar, M. Mlcek, A. Kruger, D. Vondrakova, M. Janotka, M. Popkova, O. Kittnar, P. Neuzil, P. Ostadal
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 2000
Freely Accessible Science Journals
od 2000
PubMed Central
od 2007
Europe PubMed Central
od 2007
ProQuest Central
od 2000-03-01
Open Access Digital Library
od 2000-01-01
Open Access Digital Library
od 2007-01-01
Health & Medicine (ProQuest)
od 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
od 2000
PubMed
36613937
DOI
10.3390/ijms24010493
Knihovny.cz E-zdroje
- MeSH
- funkce levé komory srdeční fyziologie MeSH
- hypoxie MeSH
- ischemická choroba srdeční * MeSH
- prasata MeSH
- srdeční frekvence fyziologie MeSH
- srdeční selhání * MeSH
- tepový objem MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
There are substantial differences in autonomic nervous system activation among heart (cardiac) failure (CF) patients. The effect of acute CF on autonomic function has not been well explored. The aim of our study was to assess the effect of experimental acute CF on heart rate variability (HRV). Twenty-four female pigs with a mean body weight of 45 kg were used. Acute severe CF was induced by global myocardial hypoxia. In each subject, two 5-min electrocardiogram segments were analyzed and compared: before the induction of myocardial hypoxia and >60 min after the development of severe CF. HRV was assessed by time-domain, frequency-domain and nonlinear analytic methods. The induction of acute CF led to a significant decrease in cardiac output, left ventricular ejection fraction and an increase in heart rate. The development of acute CF was associated with a significant reduction in the standard deviation of intervals between normal beats (50.8 [20.5−88.1] ms versus 5.9 [2.4−11.7] ms, p < 0.001). Uniform HRV reduction was also observed in other time-domain and major nonlinear analytic methods. Similarly, frequency-domain HRV parameters were significantly changed. Acute severe CF induced by global myocardial hypoxia is associated with a significant reduction in HRV.
Department of Cardiology Na Homolce Hospital 150 30 Prague Czech Republic
Department of Physiology 1st Faculty of Medicine Charles University 128 00 Prague Czech Republic
Citace poskytuje Crossref.org
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