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Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
MC. Gonzalez, DA. Tovar-Rios, G. Alves, I. Dalen, CH. Williams-Gray, M. Camacho, L. Forsgren, D. Bäckström, RA. Lawson, AD. Macleod, CE. Counsell, C. Paquet, C. DeLena, F. D'Antonio, A. Pilotto, A. Padovani, F. Blanc, C. Falup-Pecurariu, SJG....
Status neindexováno Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
PubMed Central
od 2014 do Před 1 rokem
Europe PubMed Central
od 2014 do Před 1 rokem
PubMed
37332651
DOI
10.1002/mdc3.13752
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
BACKGROUND: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). OBJECTIVES: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. METHODS: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). RESULTS: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (-1.8 [95% CI -2.3, -1.3] vs. -1.9 [95% CI -2.6, -1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). CONCLUSIONS: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.
Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya Barcelona Spain
Centre for Age Related Medicine Stavanger University Hospital Stavanger Norway
Department Neuroscience Research Institute Germans Trias i Pujol Badalona Spain
Department of Clinical Neurosciences University of Cambridge Cambridge England
Department of Clinical Science Neurosciences Umeå University Umeå Sweden
Department of Human Neurosciences Sapienza University of Rome Rome Italy
Department of Medicine and Aging Sciences University Gd'Annunzio of Chieti Pescara Chieti Italy
Department of Neurology Haukeland University Hospital Bergen Norway
Department of Neurology Medical University of Lublin Lublin Poland
Department of Neurology Stavanger University Hospital Stavanger Norway
Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK
Institute of Applied Health Sciences University of Aberdeen Aberdeen UK
Institute of Applied Health Sciences University of Aberdeen Polwarth Building Aberdeen UK
Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy
The Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway
The University of Sydney Camperdown Australia
Translational and Clinical Research Institute Newcastle University Tyne UK
Université de Paris Cognitive Neurology Center APHP Lariboisière Fernand Widal Hospital Paris France
Citace poskytuje Crossref.org
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