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Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort
I. Foeldvari, J. Klotsche, O. Kasapcopur, A. Adrovic, MT. Terreri, AP. Sakamoto, V. Stanevicha, J. Anton, BM. Feldman, F. Sztajnbok, R. Khubchandani, E. Alexeeva, M. Katsicas, S. Sawhney, V. Smith, S. Appenzeller, T. Avcin, M. Kostik, T. Lehman,...
Status neindexováno Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. METHODS: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months. RESULTS: One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease duration, and disease subtypes (70% diffuse cutaneous) were similar between males and females. Active digital ulceration, very low body mass index, and tendon friction rubs were significantly more frequent in males. Physician global assessment of disease severity and digital ulcer activity was significantly higher in males. Composite pulmonary involvement was also more frequent in males, though not statistically significantly. After 12 months, they are the pattern of differences changed female patients had significantly more frequent pulmonary involvement. CONCLUSION: In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.
AOU Meyer Children's Hospital Florence Italy
ASST Pini CTO Presidio Gaetano Pini Università degli Studi Milano Milan Italy
Charité University Medicine and German Rheumatism Research Center Berlin Berlin Germany
Children's Hospital at Montefiore Bronx NY USA
Department of General Paediatrics Asklepios Klinik Sankt Augustin Sankt Augustin Germany
Department of Paediatric and Adolescents Medicine University Hospital of Cologne Cologne Germany
Department of Pediatrics Pediatric Rheumatology Medical University Innsbruck Innsbruck Austria
Department of Women's and Children's Health Uppsala University Uppsala Sweden
German Rheumatism Research Center Berlin Germany
Great Ormond Street Hospital for Children NHS Foundation Trust London UK
Hamburg Centre for Pediatric and Adolescent Rheumatology Schön Klinik Hamburg Eilbek Hamburg Germany
Hospital de Niños Dr Orlando Alassia Santa Fe Argentina
Hospital de Pediatria J P Garrahan Buenos Aires Argentina
Hospital for Special Surgery New York NY USA
Jaslok Hospital and Research Center Mumbai India
Luzerner Kantonsspital Kinderspital Luzern Switzerland
Oslo University Hospital Oslo Norway
Pediatric Rheumatology Hospital Sant Joan de Déu Esplugues Universitat de Barcelona Barcelona Spain
Pediatric Rheumatology Sri Ramachandra University Chennai India
Pediatric Rheumatology University Tübingen Tübingen Germany
Riga Stradins University Department of Pediatric University Children Hospital Riga Latvia
Rigshospitalet Copenhagen Denmark
Saint Petersburg State Pediatric Medical University Saint Petersburg Russia
School of Medical Science University of Campinas São Paulo Brazil
Serviço de Reumatologia Hospital Garcia de Orta Almada Portugal
Sir Ganga Ram Hospital New Delhi India
Stony Brook Children's Hospital Stony Brook NY USA
The Hospital for Sick Children University of Toronto Toronto ON Canada
Universidade do Estado Rio de Janeiro Brazil
Universidade Federal de São Paulo São Paulo Brazil
University Children's Hospital University Medical Center Ljubljana Ljubljana Slovenia
University Hospital Ramón y Cajal Madrid Spain
University of Missouri Columbia Columbia MO USA
University of Pittsburgh Children's Hospital of Pittsburgh Pittsburgh PA USA
Citace poskytuje Crossref.org
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