-
Je něco špatně v tomto záznamu ?
SARS-CoV-2 Infection in Venezuelan Pediatric Patients-A Single Center Prospective Observational Study
FI. Crespo, SJ. Mayora, JB. De Sanctis, WY. Martínez, ME. Zabaleta-Lanz, FI. Toro, LH. Deibis, AH. García
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
202000PGP
Fondo Nacional de Ciencia Tecnología e Innovación
CP19-03
Ministry of Science. Venezuela
PubMed Central od 2013
Europe PubMed Central od 2013
ProQuest Central od 2013-01-01
Open Access Digital Library od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources od 2013
Odkazy
PubMed
37239080
DOI
10.3390/biomedicines11051409
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Several studies suggest that children infected with SARS-CoV-2 have fewer clinical manifestations than adults; when they develop symptoms, they rarely progress to severe disease. Different immunological theories have been proposed to explain this phenomenon. In September 2020, 16% of the active COVID-19 cases in Venezuela were children under 19 years. We conducted a cross-sectional study of pediatric patients' immune response and clinical conditions with SARS-CoV-2 infection. The patients were admitted to the COVID-19 area of the emergency department of Dr José Manuel de los Ríos Children's Hospital (2021-2022). The lymphocyte subpopulations were analyzed by flow cytometry, and IFNγ, IL-6, and IL-10 serum concentrations were quantified using commercial ELISA assays. The analysis was conducted on 72 patients aged one month to 18 years. The majority, 52.8%, had mild disease, and 30.6% of the patients were diagnosed with MIS-C. The main symptoms reported were fever, cough, and diarrhea. A correlation was found between IL-10 and IL-6 concentrations and age group, lymphocyte subpopulations and nutritional status and steroid use, and IL-6 concentrations and clinical severity. The results suggest a different immune response depending on age and nutritional status that should be considered for treating pediatric COVID-19 patients.
Czech Advanced Technology and Research Institute Palacky University 779 00 Olomouc Czech Republic
Institute of Immunology Faculty of Medicine Central University of Venezuela Caracas 1040 Venezuela
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23009805
- 003
- CZ-PrNML
- 005
- 20230721095443.0
- 007
- ta
- 008
- 230707s2023 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/biomedicines11051409 $2 doi
- 035 __
- $a (PubMed)37239080
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Crespo, Francis Isamarg $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 245 10
- $a SARS-CoV-2 Infection in Venezuelan Pediatric Patients-A Single Center Prospective Observational Study / $c FI. Crespo, SJ. Mayora, JB. De Sanctis, WY. Martínez, ME. Zabaleta-Lanz, FI. Toro, LH. Deibis, AH. García
- 520 9_
- $a Several studies suggest that children infected with SARS-CoV-2 have fewer clinical manifestations than adults; when they develop symptoms, they rarely progress to severe disease. Different immunological theories have been proposed to explain this phenomenon. In September 2020, 16% of the active COVID-19 cases in Venezuela were children under 19 years. We conducted a cross-sectional study of pediatric patients' immune response and clinical conditions with SARS-CoV-2 infection. The patients were admitted to the COVID-19 area of the emergency department of Dr José Manuel de los Ríos Children's Hospital (2021-2022). The lymphocyte subpopulations were analyzed by flow cytometry, and IFNγ, IL-6, and IL-10 serum concentrations were quantified using commercial ELISA assays. The analysis was conducted on 72 patients aged one month to 18 years. The majority, 52.8%, had mild disease, and 30.6% of the patients were diagnosed with MIS-C. The main symptoms reported were fever, cough, and diarrhea. A correlation was found between IL-10 and IL-6 concentrations and age group, lymphocyte subpopulations and nutritional status and steroid use, and IL-6 concentrations and clinical severity. The results suggest a different immune response depending on age and nutritional status that should be considered for treating pediatric COVID-19 patients.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Mayora, Soriuska José $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 700 1_
- $a De Sanctis, Juan Bautista $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic $u Czech Advanced Technology and Research Institute, Palacky University, 779 00 Olomouc, Czech Republic $1 https://orcid.org/0000000254804608
- 700 1_
- $a Martínez, Wendy Yaqueline $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 700 1_
- $a Zabaleta-Lanz, Mercedes Elizabeth $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 700 1_
- $a Toro, Félix Isidro $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 700 1_
- $a Deibis, Leopoldo Humberto $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela
- 700 1_
- $a García, Alexis Hipólito $u Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas 1040, Venezuela $1 https://orcid.org/0000000223540160
- 773 0_
- $w MED00205373 $t Biomedicines $x 2227-9059 $g Roč. 11, č. 5 (2023)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/37239080 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230707 $b ABA008
- 991 __
- $a 20230721095437 $b ABA008
- 999 __
- $a ok $b bmc $g 1958509 $s 1196069
- BAS __
- $a 3
- BAS __
- $a PreBMC-PubMed-not-MEDLINE
- BMC __
- $a 2023 $b 11 $c 5 $e 20230509 $i 2227-9059 $m Biomedicines $n Biomedicines $x MED00205373
- GRA __
- $a 202000PGP $p Fondo Nacional de Ciencia Tecnología e Innovación
- GRA __
- $a CP19-03 $p Ministry of Science. Venezuela
- LZP __
- $a Pubmed-20230707