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G-quadruplex ligands as potent regulators of lysosomes
L. Ferret, K. Alvarez-Valadez, J. Rivière, A. Muller, N. Bohálová, L. Yu, L. Guittat, V. Brázda, G. Kroemer, JL. Mergny, M. Djavaheri-Mergny
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 2005 do Před 1 rokem
PubMed Central
od 2006 do Před 1 rokem
Europe PubMed Central
od 2008 do Před 1 rokem
- MeSH
- autofagie * MeSH
- DNA metabolismus MeSH
- G-kvadruplexy * MeSH
- guanin MeSH
- lidé MeSH
- ligandy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Guanine-quadruplex structures (G4) are unusual nucleic acid conformations formed by guanine-rich DNA and RNA sequences and known to control gene expression mechanisms, from transcription to protein synthesis. So far, a number of molecules that recognize G4 have been developed for potential therapeutic applications in human pathologies, including cancer and infectious diseases. These molecules are called G4 ligands. When the biological effects of G4 ligands are studied, the analysis is often limited to nucleic acid targets. However, recent evidence indicates that G4 ligands may target other cellular components and compartments such as lysosomes and mitochondria. Here, we summarize our current knowledge of the regulation of lysosome by G4 ligands, underlying their potential functional impact on lysosome biology and autophagic flux, as well as on the transcriptional regulation of lysosomal genes. We outline the consequences of these effects on cell fate decisions and we systematically analyzed G4-prone sequences within the promoter of 435 lysosome-related genes. Finally, we propose some hypotheses about the mechanisms involved in the regulation of lysosomes by G4 ligands.
CNRS UMR9187 INSERM U1196 Université Paris Saclay Orsay France
Department of Medicine 3 Klinikum Rechts der Isar Technical University of Munich Munich Germany
Metabolomics and Cell Biology Platforms Institut Gustave Roussy Villejuif France
Citace poskytuje Crossref.org
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