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Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post-CD19-directed CAR T-cell therapy: an EPICOVIDEHA survey

JA. van Doesum, J. Salmanton-García, F. Marchesi, R. Di Blasi, I. Falces-Romero, A. Cabirta, F. Farina, C. Besson, B. Weinbergerová, J. Van Praet, M. Schönlein, A. López-García, S. Lamure, A. Guidetti, C. De Ramón-Sánchez, J. Batinić, E....

. 2023 ; 7 (11) : 2645-2655. [pub] 2023Jun13

Jazyk angličtina Země Spojené státy americké

Typ dokumentu multicentrická studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23011065

Patients with previous CD19-directed chimeric antigen receptor (CAR) T-cell therapy have a prolonged vulnerability to viral infections. Coronavirus disease 2019 (COVID-19) has a great impact and has previously been shown to cause high mortality in this population. Until now, real-world data on the impact of vaccination and treatment on patients with COVID-19 after CD19-directed CAR T-cell therapy are lacking. Therefore, this multicenter, retrospective study was conducted with data from the EPICOVIDEHA survey. Sixty-four patients were identified. The overall mortality caused by COVID-19 was 31%. Patients infected with the Omicron variant had a significantly lower risk of death due to COVID-19 compared with patients infected with previous variants (7% vs 58% [P = .012]). Twenty-six patients were vaccinated at the time of the COVID-19 diagnosis. Two vaccinations showed a marked but unsignificant reduction in the risk of COVID-19-caused mortality (33.3% vs 14.2% [P = .379]). In addition, the course of the disease appears milder with less frequent intensive care unit admissions (39% vs 14% [P = .054]) and a shorter duration of hospitalization (7 vs 27.5 days [P = .022]). Of the available treatment options, only monoclonal antibodies seemed to be effective at reducing mortality from 32% to 0% (P = .036). We conclude that survival rates of CAR T-cell recipients with COVID-19 improved over time and that the combination of prior vaccination and monoclonal antibody treatment significantly reduces their risk of death. This trial was registered at www.clinicaltrials.gov as #NCT04733729.

Aristotle University of Thessaloniki Thessaloniki Greece

Azienda Ospedaliera Nazionale SS Antonio e Biagio e Cesare Arrigo Alessandria Italy

Centre Hospitalier d'Argenteuil Argenteuil France

Centre Hospitalier de Versailles Le Chesnay France

Centro de Investigación Biomédica en Red Instituto de Salud Carlos 3 Madrid Spain

Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Marañón Madrid Spain

Complejo Hospitalario de Navarra Iruña Pamplona Spain

Departament de Medicina Universitat Autònoma de Barcelona Bellaterra Spain

Department 1 of Internal Medicine Faculty of Medicine and University Hospital Cologne Excellence Center for Medical Mycology University of Cologne Cologne Germany

Department of Clinical Hematology Montpellier University Hospital IGMM UMR5535 CNRS University of Montpellier Montpellier France

Department of Hematology and Oncology Medical University of Innsbruck Innsbruck Austria

Department of Hematology University Hospital Virgen Macarena University Hospital Virgen del Rocío Instituto de Biomedicina de Sevilla Seville Spain

Department of Hematology UZ Leuven Leuven Belgium

Department of Hematology Vall d'Hebron Hospital Universitari Experimental Hematology Vall d'Hebron Institute of Oncology Vall d'Hebron Barcelona Hospital Campus Barcelona Spain

Department of Infectious Diseases Karolinska University Hospital Stockholm Sweden

Department of Internal Medicine Hematology and Oncology Masaryk University Hospital Brno Brno Czech Republic

Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium

Department of Nephrology and Infectious Diseases AZ Sint Jan Brugge Oostende AV Brugge Belgium

Department of Oncohematology Comenius University and National Cancer Institute Bratislava Slovakia

Department of Oncology Hematology and Bone Marrow Transplantation with Section of Pneumology University Medical Center Hamburg Eppendorf Hamburg Germany

Faculty of Medicine and University Hospital Cologne Center for Molecular Medicine Cologne University of Cologne Cologne Germany

Faculty of Medicine and University Hospital Cologne Institute of Translational Research Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases University of Cologne Cologne Germany

Faculty of Medicine University Medical Center Hamburg Eppendorf Hamburg Germany

Fundacion Jimenez Diaz University Hospital Health Research Institute IIS FJD Madrid Spain

German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany

Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute Rome Italy

Hematology Department Hospital Universitario de Salamanca Salamanca Spain

Hematology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy

Hospital Universitario 12 de Octubre Madrid Spain

Hospital Universitario Infanta Leonor Madrid Spain

Hospital Universitario Marqués de Valdecilla Santander Spain

Hospital Univesitario Virgen del Rocío Seville Spain

Instituto de Investigación Biomédica de Salamanca Centro de Investigación del Cáncer IBMCC Salamanca Spain

IRCCS Ospedale San Raffaele Milan Italy

Istituto Oncologico della Svizzera Italiana Bellinzona Switzerland

King's College Hospital London United Kingdom

La Paz University Hospital Madrid Spain

Ospedale San Bortolo Vicenza Italy

Portuguese Institute of Oncology Lisbon Portugal

School of Medicine University of Zagreb Zagreb Croatia

Service d'Hematologie Oncologie Hopital St Louis Assistance Publique Hopitaux de Paris Paris France

Universite de Paris Diderot Paris France

Université Paris Saclay Université de Versailles Saint Quentin en Yvelines INSERM Équipe Exposome et Hérédité Centre for Epidemiology and Population Health Villejuif France

University Hospital Centre Zagreb Zagreb Croatia

University Medical Center Groningen Groningen The Netherlands

University of Cologne Faculty of Medicine and University Hospital Cologne Clinical Trials Centre Cologne Cologne Germany

University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Cologne Germany

University of Milan and Fondazione IRCCS Istituto Nazionale Dei Tumori Milan Italy

Citace poskytuje Crossref.org

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