• Je něco špatně v tomto záznamu ?

Calcified Chondroid Mesenchymal Neoplasm: Exploring the Morphologic and Clinical Features of an Emergent Entity With a Series of 33 Cases

ME. Kallen, M. Michal, A. Meyer, DI. Suster, NJ. Olson, GW. Charville, R. Perret, JM. Gross

. 2023 ; 47 (6) : 725-737. [pub] 20230427

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23011196

Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23011196
003      
CZ-PrNML
005      
20230801132850.0
007      
ta
008      
230718s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1097/PAS.0000000000002044 $2 doi
035    __
$a (PubMed)37102574
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kallen, Michael E $u Department of Pathology, University of Maryland School of Medicine
245    10
$a Calcified Chondroid Mesenchymal Neoplasm: Exploring the Morphologic and Clinical Features of an Emergent Entity With a Series of 33 Cases / $c ME. Kallen, M. Michal, A. Meyer, DI. Suster, NJ. Olson, GW. Charville, R. Perret, JM. Gross
520    9_
$a Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma.
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a lidé středního věku $7 D008875
650    12
$a nádory z pojivové a měkké tkáně $x diagnostické zobrazování $x genetika $7 D018204
650    12
$a chondrosarkom $x patologie $7 D002813
650    _2
$a chrupavka $x patologie $7 D002356
650    _2
$a prsty nohy $x patologie $7 D014034
650    12
$a nádory kostí $x diagnostické zobrazování $x genetika $x patologie $7 D001859
655    _2
$a časopisecké články $7 D016428
700    1_
$a Michal, Michael $u Biopticka Laboratory, Pilsen, Czech Republic
700    1_
$a Meyer, Anders $u Department of Pathology and Laboratory Medicine, University of Kansas School of Medicine, Kansas City, KS
700    1_
$a Suster, David I $u Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Rutgers, NJ
700    1_
$a Olson, Nicholas J $u Physicians Laboratory $u University of South Dakota Sanford School of Medicine, Sioux Falls, SD
700    1_
$a Charville, Gregory W $u Department of Pathology, Stanford Medicine, Stanford, CA
700    1_
$a Perret, Raul $u Institut Bergonié / Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
700    1_
$a Gross, John M $u Department of Pathology, Johns Hopkins Medicine, Baltimore, MD
773    0_
$w MED00000304 $t The American journal of surgical pathology $x 1532-0979 $g Roč. 47, č. 6 (2023), s. 725-737
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37102574 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230718 $b ABA008
991    __
$a 20230801132847 $b ABA008
999    __
$a ok $b bmc $g 1963531 $s 1197461
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 47 $c 6 $d 725-737 $e 20230427 $i 1532-0979 $m The American journal of surgical pathology $n Am J Surg Pathol $x MED00000304
LZP    __
$a Pubmed-20230718

Najít záznam

Citační ukazatele

Možnosti archivace