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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
HM. Ollila, E. Sharon, L. Lin, N. Sinnott-Armstrong, A. Ambati, SM. Yogeshwar, RP. Hillary, O. Jolanki, J. Faraco, M. Einen, G. Luo, J. Zhang, F. Han, H. Yan, XS. Dong, J. Li, J. Zhang, SC. Hong, TW. Kim, Y. Dauvilliers, L. Barateau, GJ. Lammers,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- autoimunita genetika MeSH
- autoimunitní nemoci * epidemiologie genetika MeSH
- chřipka lidská * epidemiologie genetika MeSH
- lidé MeSH
- narkolepsie * chemicky indukované genetika MeSH
- vakcíny proti chřipce * škodlivé účinky MeSH
- virus chřipky A, podtyp H1N1 * genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.
Center for Applied Biomedical Research St Orsola Malpighi University Hospital Bologna Italy
Center for Genomic Medicine Massachusetts General Hospital Boston MA USA
Center for Sleep Medicine and Sleep Research Clinic Barmelweid AG Barmelweid Switzerland
Charité Universitätsmedizin Berlin Einstein Center for Neurosciences Berlin 10117 Berlin Germany
Coliseum on Majorstua Clinic Oslo Norway
Department of Biology Stanford University Stanford CA 94305 USA
Department of Biomedical Data Science Administration Stanford University Palo Alto CA USA
Department of Clinical Neurophysiology Institute of Psychiatry and Neurology Warsaw Poland
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Clinical Neurosciences University of Helsinki Helsinki Finland
Department of Genetics Stanford University Stanford CA 94305 USA
Department of Human Genetics Graduate School of Medicine The University of Tokyo Tokyo Japan
Department of Medical Sciences and Science for Life Laboratory Uppsala University Uppsala Sweden
Department of Neurology Barcelona Spain
Department of Neurology Charité Universitätsmedizin 10117 Berlin Germany
Department of Neurology Emory University School of Medicine Atlanta GA USA
Department of Neurology Inselspital Bern University Hospital and University of Bern Bern Switzerland
Department of Neurology Leiden University Medical Center Leiden The Netherlands
Department of Neurology Medical University Innsbruck Innsbruck Austria
Department of Neurology The Peking University People's Hospital Beijing China
Department of Neuropsychiatry Akita University Graduate School of Medicine Akita Japan
Department of Neuroscience University of Copenhagen Copenhagen Denmark
Department of Psychiatry and Behavioral Sciences Stanford University Palo Alto CA USA
Department of Psychiatry and Psychotherapy University of Regensburg Regensburg Germany
Department of Psychiatry St Vincent's Hospital The Catholic University of Korea Suwon Korea
Department of Sleep Medicine Strasbourg University Hospital Strasbourg University Strasbourg France
Dept Epidemiology and Biostatistics UCSF 513 Parnassus Avenue San Francisco CA 94117 USA
Division of Child and Adolescent Psychiatry Karolinska Institutet Stockholm Sweden
Division of Research Kaiser Permanente Northern California Oakland CA USA
Division of Sleep Medicine The Peking University People's Hospital Beijing China
Eindhoven University of Technology Eindhoven The Netherlands
Faculty of Health Sciences Hasan Kalyoncu University Gaziantep Turkey
Helsinki Sleep Clinic Vitalmed Research Centre Helsinki Finland
Hephata Klinik Schimmelpfengstr 6 34613 Schwalmstadt Germany
Hormone Laboratory Department of Medical Biochemistry Oslo University Hospital Oslo Norway
Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
Institute for Molecular Medicine Finland HiLIFE University of Helsinki Helsinki Finland
Institute for Neurosciences of Montpellier INSERM Université Montpellier 1 Montpellier France
International Institute for Integrative Sleep Medicine University of Tsukuba Tsukuba Japan
IRCCS Institute of Neurological Sciences Bologna Italy
Mater Private Hospital Dublin 7 Ireland
Mental Illness Research Education Clinical Centers VA Palo Alto Palo Alto CA USA
Multidisciplinary Sleep Disorders Unit Barcelona Spain
Munich Cluster for Systems Neurology Munich Germany
Neurology Department EOC Ospedale Regionale di Lugano Lugano Ticino Switzerland
Neurology Service Institut de Neurociències Hospital Clínic University of Barcelona Barcelona Spain
Philipps Universität Marburg Baldinger Str 35043 Marburg Germany
Seiwa Hospital Neuropsychiatric Research Institute Tokyo Japan
Shaare Zedek Medical Center Jerusalem Israel
Sleep Medicine Center Kempenhaeghe P O Box 61 5590 AB Heeze The Netherlands
Sleep Unit Medical Center Valencia Valencia Spain
Stichting Epilepsie Instellingen Nederland Sleep Wake Centre Heemstede The Netherlands
Swiss Institute of Bioinformatics Lausanne Switzerland
Universidade Federal de São Paulo Departamento de Psicobiologia São Paulo Brazil
Citace poskytuje Crossref.org
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- $a ok $b bmc $g 1963694 $s 1197699
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 14 $c 1 $d 2709 $e 20230515 $i 2041-1723 $m Nature communications $n Nat Commun $x MED00184850
- LZP __
- $a Pubmed-20230718
