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Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts

J. Stochl, H. Jones, E. Soneson, AP. Wagner, GM. Khandaker, S. Zammit, J. Heron, G. Hammerton, ET. Bullmore, R. Dolan, P. Fonagy, IM. Goodyer, J. Perez, PB. Jones

. 2023 ; 32 (5) : 797-807. [pub] 20211118

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23011673

Grantová podpora
201486/Z/16/Z Wellcome Trust - United Kingdom
MQDS17/40 MQ: Transforming Mental Health - United Kingdom
MR/L010305/1 Medical Research Council - United Kingdom
209138/Z/17/Z Wellcome Trust - United Kingdom
MC_G0802534 Medical Research Council - United Kingdom
095844/Z/11/Z Wellcome Trust - United Kingdom
MR/L022206/1 Medical Research Council - United Kingdom
MC_PC_17213 Medical Research Council - United Kingdom

Characterizing patterns of mental phenomena in epidemiological studies of adolescents can provide insight into the latent organization of psychiatric disorders. This avoids the biases of chronicity and selection inherent in clinical samples, guides models of shared aetiology within psychiatric disorders and informs the development and implementation of interventions. We applied Gaussian mixture modelling to measures of mental phenomena from two general population cohorts: the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 3018) and the Neuroscience in Psychiatry Network (NSPN, n = 2023). We defined classes according to their patterns of both positive (e.g. wellbeing and self-esteem) and negative (e.g. depression, anxiety, and psychotic experiences) phenomena. Subsequently, we characterized classes by considering the distribution of diagnoses and sex split across classes. Four well-separated classes were identified within each cohort. Classes primarily differed by overall severity of transdiagnostic distress rather than particular patterns of phenomena akin to diagnoses. Further, as overall severity of distress increased, so did within-class variability, the proportion of individuals with operational psychiatric diagnoses. These results suggest that classes of mental phenomena in the general population of adolescents may not be the same as those found in clinical samples. Classes differentiated only by overall severity support the existence of a general, transdiagnostic mental distress factor and have important implications for intervention.

Citace poskytuje Crossref.org

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