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Autonomic modulation, spontaneous baroreflex sensitivity and fatigue in young men after COVID-19

PL. Latchman, Q. Yang, D. Morgenthaler, L. Kong, J. Sebagisha, L. Melendez, CA. Green, S. Bernard, R. Mugno, R. De Meersman

. 2023 ; 72 (3) : 329-336. [pub] 2023Jul14

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc23012418

Impaired autonomic modulation and baroreflex sensitivity (BRS) have been reported during and after COVID-19. Both impairments are associated with negative cardiovascular outcomes. If these impairments were to exist undetected in young men after COVID-19, they could lead to negative cardiovascular outcomes. Fatigue is associated with autonomic dysfunction during and after COVID-19. It is unclear if fatigue can be used as an indicator of impaired autonomic modulation and BRS after COVID-19. This study aims to compare parasympathetic modulation, sympathetic modulation, and BRS between young men who had COVID-19 versus controls and to determine if fatigue is associated with impaired autonomic modulation and BRS. Parasympathetic modulation as the high-frequency power of R-R intervals (lnHFR-R), sympathetic modulation as the low-frequency power of systolic blood pressure variability (LFSBP), and BRS as the -index were measured by power spectral density analysis. These variables were compared between 20 young men who had COVID-19 and 24 controls. Independent t-tests and Mann-Whitney U tests indicated no significant difference between the COVID-19 and the control group in: lnHFR-R, P=0.20; LFSBP, P=0.11, and -index, P=0.20. Fatigue was not associated with impaired autonomic modulation or BRS. There is no difference in autonomic modulations or BRS between young men who had COVID-19 compared to controls. Fatigue did not seem to be associated with impaired autonomic modulation or impaired BRS in young men after COVID-19. Findings suggest that young men might not be at increased cardiovascular risk from COVID-19-related dysautonomia and impaired BRS.

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$a Impaired autonomic modulation and baroreflex sensitivity (BRS) have been reported during and after COVID-19. Both impairments are associated with negative cardiovascular outcomes. If these impairments were to exist undetected in young men after COVID-19, they could lead to negative cardiovascular outcomes. Fatigue is associated with autonomic dysfunction during and after COVID-19. It is unclear if fatigue can be used as an indicator of impaired autonomic modulation and BRS after COVID-19. This study aims to compare parasympathetic modulation, sympathetic modulation, and BRS between young men who had COVID-19 versus controls and to determine if fatigue is associated with impaired autonomic modulation and BRS. Parasympathetic modulation as the high-frequency power of R-R intervals (lnHFR-R), sympathetic modulation as the low-frequency power of systolic blood pressure variability (LFSBP), and BRS as the -index were measured by power spectral density analysis. These variables were compared between 20 young men who had COVID-19 and 24 controls. Independent t-tests and Mann-Whitney U tests indicated no significant difference between the COVID-19 and the control group in: lnHFR-R, P=0.20; LFSBP, P=0.11, and -index, P=0.20. Fatigue was not associated with impaired autonomic modulation or BRS. There is no difference in autonomic modulations or BRS between young men who had COVID-19 compared to controls. Fatigue did not seem to be associated with impaired autonomic modulation or impaired BRS in young men after COVID-19. Findings suggest that young men might not be at increased cardiovascular risk from COVID-19-related dysautonomia and impaired BRS.
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$a Yang, Qin $u School of Health Promotion and Kinesiology, Texas Woman’s University, Denton, Texas, USA
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$a Morgenthaler, Diane $u Southern Connecticut State University, Health Services, New Haven, Connecticut, USA
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$a Kong, Lingsong $u Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts, USA
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$a Sebagisha, Josephine $u Clinical Department St. James School of Medicine, Chicago, Illinois, USA
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$a Melendez, Luke $u Southern Connecticut State University, Department of Public Health, New Haven, Connecticut, USA
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$a Green, Cheryl A. $u Southern Connecticut State University, Department of Nursing, New Haven, Connecticut, USA
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$a Bernard, Stanley $u Southern Connecticut State University, Department of Public Health, New Haven, Connecticut, USA
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$a Mugno, Raymond $u Southern Connecticut State University, Department of Mathematics, New Haven, Connecticut, USA
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$a De Meersman, Ronald $u Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, New York, USA
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