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The importance and control of the nucleation process for the crystallization of pharmaceutical substances

Roman Gabriel, Adéla Benýšek Bártová, Damir Šahnić, Bohumil Kratochvíl

. 2022 ; 116 (12) : 737-745.

Jazyk angličtina Země Česko

Typ dokumentu přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc23013829

The text is a contemporary continuation of an earlier publication, Kratochvíl B.: Chem. Listy 101, 3 (2007). It describes mainly the nucleation process (two-step nuclea-tion of active substances in pharmacy) and crystallization control processes (seeded crystallization and sonocrystalli-zation). The focus of the work is the description of the nucleation process monitoring by modern analytical tech-nologies, i.e., Focused Beam Reflectance Measurement (FBRM) and the BlazeMetrics system. Both methods pres-ently provide the best available information for a deeper understanding of the nucleation process mechanism in crystallizing active substances. The work is documented by high quality and original photographic attachments of the crystallizing material.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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