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COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT
V. Geudens, J. Van Slambrouck, G. Aerts, L. Willems, T. Goos, J. Kaes, A. Zajacova, I. Gyselinck, C. Aelbrecht, A. Vermaut, H. Beeckmans, M. Vermant, C. De Fays, A. Sacreas, L. Aversa, M. Orlitova, A. Vanstapel, I. Josipovic, MN. Boone, JE....
Status neindexováno Jazyk angličtina Země Čína
Typ dokumentu časopisecké články
Odkazy
PubMed
37559650
DOI
10.21037/jtd-22-1488
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19) which can lead to acute respiratory distress syndrome (ARDS) and evolve to pulmonary fibrosis. Computed tomography (CT) is used to study disease progression and describe radiological patterns in COVID-19 patients. This study aimed to assess disease progression regarding lung volume and density over time on follow-up in vivo chest CT and give a unique look at parenchymal and morphological airway changes in "end-stage" COVID-19 lungs using ex vivo microCT. METHODS: Volumes and densities of the lung/lobes of three COVID-19 patients were assessed using follow-up in vivo CT and ex vivo whole lung microCT scans. Airways were quantified by airway segmentations on whole lung microCT and small-partition microCT. As controls, three discarded healthy donor lungs were used. Histology was performed in differently affected regions in the COVID-19 lungs. RESULTS: In vivo, COVID-19 lung volumes decreased while density increased over time, mainly in lower lobes as previously shown. Ex vivo COVID-19 lung volumes decreased by 60% and all lobes were smaller compared to controls. Airways were more visible on ex vivo microCT in COVID-19, probably due to fibrosis and increased airway diameter. In addition, small-partition microCT showed more deformation of (small) airway morphology and fibrotic organization in severely affected regions with heterogeneous distributions within the same lung which was confirmed by histology. CONCLUSIONS: COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.
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- $a Geudens, Vincent $u Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
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- $a COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT / $c V. Geudens, J. Van Slambrouck, G. Aerts, L. Willems, T. Goos, J. Kaes, A. Zajacova, I. Gyselinck, C. Aelbrecht, A. Vermaut, H. Beeckmans, M. Vermant, C. De Fays, A. Sacreas, L. Aversa, M. Orlitova, A. Vanstapel, I. Josipovic, MN. Boone, JE. McDonough, B. Weynand, C. Pilette, W. Janssens, L. Dupont, WA. Wuyts, GM. Verleden, DE. Van Raemdonck, R. Vos, G. Gayan-Ramirez, LJ. Ceulemans, BM. Vanaudenaerde
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- $a BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19) which can lead to acute respiratory distress syndrome (ARDS) and evolve to pulmonary fibrosis. Computed tomography (CT) is used to study disease progression and describe radiological patterns in COVID-19 patients. This study aimed to assess disease progression regarding lung volume and density over time on follow-up in vivo chest CT and give a unique look at parenchymal and morphological airway changes in "end-stage" COVID-19 lungs using ex vivo microCT. METHODS: Volumes and densities of the lung/lobes of three COVID-19 patients were assessed using follow-up in vivo CT and ex vivo whole lung microCT scans. Airways were quantified by airway segmentations on whole lung microCT and small-partition microCT. As controls, three discarded healthy donor lungs were used. Histology was performed in differently affected regions in the COVID-19 lungs. RESULTS: In vivo, COVID-19 lung volumes decreased while density increased over time, mainly in lower lobes as previously shown. Ex vivo COVID-19 lung volumes decreased by 60% and all lobes were smaller compared to controls. Airways were more visible on ex vivo microCT in COVID-19, probably due to fibrosis and increased airway diameter. In addition, small-partition microCT showed more deformation of (small) airway morphology and fibrotic organization in severely affected regions with heterogeneous distributions within the same lung which was confirmed by histology. CONCLUSIONS: COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.
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- $a Van Slambrouck, Jan $u Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
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- $a Aerts, Gitte $u Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
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- $a Willems, Lynn $u Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
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- $a Zajacova, Andrea $u Prague Lung Transplant Program, Department of Pneumology, Motol University Hospital, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
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- $a Josipovic, Ivan $u Department of Physics and Astronomy, Centre for X-Ray Tomography (UGCT), Radiation Physics, Ghent University, Gent, Belgium
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- $a McDonough, John E $u Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA
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- $a Weynand, Birgit $u Department of Imaging & Pathology, KU Leuven, Leuven, Belgium
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- $a Wuyts, Wim A $u Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
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