• Je něco špatně v tomto záznamu ?

Hydrophilic Copolymers with Hydroxamic Acid Groups as a Protective Biocompatible Coating of Maghemite Nanoparticles: Synthesis, Physico-Chemical Characterization and MRI Biodistribution Study

H. Charvátová, Z. Plichta, J. Hromádková, V. Herynek, M. Babič

. 2023 ; 15 (7) : . [pub] 20230719

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23015695

Grantová podpora
Programme EXCELES, ID Project No. LX22NPO5102 European Union
Large RI Project LM2023050 Czech-BioImaging Ministry of Education, Youth and Sports of the Czech Republic
CZ.02.1.01/0.0/0.0/16_013/0001775 European Regional Development Fund

Superparamagnetic iron oxide nanoparticles (SPION) with a "non-fouling" surface represent a versatile group of biocompatible nanomaterials valuable for medical diagnostics, including oncology. In our study we present a synthesis of novel maghemite (γ-Fe2O3) nanoparticles with positive and negative overall surface charge and their coating by copolymer P(HPMA-co-HAO) prepared by RAFT (reversible addition-fragmentation chain-transfer) copolymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) with N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide (HAO). Coating was realized via hydroxamic acid groups of the HAO comonomer units with a strong affinity to maghemite. Dynamic light scattering (DLS) demonstrated high colloidal stability of the coated particles in a wide pH range, high ionic strength, and the presence of phosphate buffer (PBS) and serum albumin (BSE). Transmission electron microscopy (TEM) images show a narrow size distribution and spheroid shape. Alternative coatings were prepared by copolymerization of HPMA with methyl 2-(2-methylprop-2-enoylamino)acetate (MMA) and further post-polymerization modification with hydroxamic acid groups, carboxylic acid and primary-amino functionalities. Nevertheless, their colloidal stability was worse in comparison with P(HPMA-co-HAO). Additionally, P(HPMA-co-HAO)-coated nanoparticles were subjected to a bio-distribution study in mice. They were cleared from the blood stream by the liver relatively slowly, and their half-life in the liver depended on their charge; nevertheless, both cationic and anionic particles revealed a much shorter metabolic clearance rate than that of commercially available ferucarbotran.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23015695
003      
CZ-PrNML
005      
20231020093524.0
007      
ta
008      
231010s2023 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/pharmaceutics15071982 $2 doi
035    __
$a (PubMed)37514168
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Charvátová, Hana $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského Náměstí 2, 162 06 Prague, Czech Republic
245    10
$a Hydrophilic Copolymers with Hydroxamic Acid Groups as a Protective Biocompatible Coating of Maghemite Nanoparticles: Synthesis, Physico-Chemical Characterization and MRI Biodistribution Study / $c H. Charvátová, Z. Plichta, J. Hromádková, V. Herynek, M. Babič
520    9_
$a Superparamagnetic iron oxide nanoparticles (SPION) with a "non-fouling" surface represent a versatile group of biocompatible nanomaterials valuable for medical diagnostics, including oncology. In our study we present a synthesis of novel maghemite (γ-Fe2O3) nanoparticles with positive and negative overall surface charge and their coating by copolymer P(HPMA-co-HAO) prepared by RAFT (reversible addition-fragmentation chain-transfer) copolymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) with N-[2-(hydroxyamino)-2-oxo-ethyl]-2-methyl-prop-2-enamide (HAO). Coating was realized via hydroxamic acid groups of the HAO comonomer units with a strong affinity to maghemite. Dynamic light scattering (DLS) demonstrated high colloidal stability of the coated particles in a wide pH range, high ionic strength, and the presence of phosphate buffer (PBS) and serum albumin (BSE). Transmission electron microscopy (TEM) images show a narrow size distribution and spheroid shape. Alternative coatings were prepared by copolymerization of HPMA with methyl 2-(2-methylprop-2-enoylamino)acetate (MMA) and further post-polymerization modification with hydroxamic acid groups, carboxylic acid and primary-amino functionalities. Nevertheless, their colloidal stability was worse in comparison with P(HPMA-co-HAO). Additionally, P(HPMA-co-HAO)-coated nanoparticles were subjected to a bio-distribution study in mice. They were cleared from the blood stream by the liver relatively slowly, and their half-life in the liver depended on their charge; nevertheless, both cationic and anionic particles revealed a much shorter metabolic clearance rate than that of commercially available ferucarbotran.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Plichta, Zdeněk $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského Náměstí 2, 162 06 Prague, Czech Republic
700    1_
$a Hromádková, Jiřina $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského Náměstí 2, 162 06 Prague, Czech Republic
700    1_
$a Herynek, Vít $u Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, 120 00 Prague, Czech Republic
700    1_
$a Babič, Michal $u Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského Náměstí 2, 162 06 Prague, Czech Republic
773    0_
$w MED00186380 $t Pharmaceutics $x 1999-4923 $g Roč. 15, č. 7 (2023)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37514168 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20231010 $b ABA008
991    __
$a 20231020093518 $b ABA008
999    __
$a ok $b bmc $g 1997230 $s 1202057
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 15 $c 7 $e 20230719 $i 1999-4923 $m Pharmaceutics $n Pharmaceutics $x MED00186380
GRA    __
$a Programme EXCELES, ID Project No. LX22NPO5102 $p European Union
GRA    __
$a Large RI Project LM2023050 Czech-BioImaging $p Ministry of Education, Youth and Sports of the Czech Republic
GRA    __
$a CZ.02.1.01/0.0/0.0/16_013/0001775 $p European Regional Development Fund
LZP    __
$a Pubmed-20231010

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...