-
Something wrong with this record ?
Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos
A. Lisachov, K. Tishakova, S. Romanenko, L. Lisachova, G. Davletshina, D. Prokopov, L. Kratochvíl, P. O Brien, M. Ferguson-Smith, P. Borodin, V. Trifonov
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2011
Free Medical Journals
from 2011
Nature Open Access
from 2011-12-01
PubMed Central
from 2011
Europe PubMed Central
from 2011
ProQuest Central
from 2011-01-01
Open Access Digital Library
from 2011-01-01
Open Access Digital Library
from 2011-01-01
Health & Medicine (ProQuest)
from 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2011
Springer Nature OA/Free Journals
from 2011-12-01
- MeSH
- Y Chromosome genetics MeSH
- Lizards * genetics MeSH
- Sex Chromosomes genetics MeSH
- Cell Movement MeSH
- Recombination, Genetic MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.
Department of Ecology Faculty of Science Charles University 12844 Prague Czech Republic
Institute of Environmental and Agricultural Biology University of Tyumen Tyumen 625003 Russia
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23016209
- 003
- CZ-PrNML
- 005
- 20231026110207.0
- 007
- ta
- 008
- 231013s2023 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41598-023-39937-2 $2 doi
- 035 __
- $a (PubMed)37726346
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Lisachov, Artem $u Animal Genomics and Bioresource Research Unit (AGB Research Unit), Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand. aplisachev@gmail.com $u Institute of Environmental and Agricultural Biology (X-BIO), University of Tyumen, Tyumen, 625003, Russia. aplisachev@gmail.com $u Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia. aplisachev@gmail.com
- 245 10
- $a Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos / $c A. Lisachov, K. Tishakova, S. Romanenko, L. Lisachova, G. Davletshina, D. Prokopov, L. Kratochvíl, P. O Brien, M. Ferguson-Smith, P. Borodin, V. Trifonov
- 520 9_
- $a The classical hypothesis proposes that the lack of recombination on sex chromosomes arises due to selection for linkage between a sex-determining locus and sexually antagonistic loci, primarily facilitated by inversions. However, cessation of recombination on sex chromosomes could be attributed also to neutral processes, connected with other chromosome rearrangements or can reflect sex-specific recombination patterns existing already before sex chromosome differentiation. Three Coleonyx gecko species share a complex X1X1X2X2/X1X2Y system of sex chromosomes evolved via a fusion of the Y chromosome with an autosome. We analyzed synaptonemal complexes and sequenced flow-sorted sex chromosomes to investigate the effect of chromosomal rearrangement on recombination and differentiation of these sex chromosomes. The gecko sex chromosomes evolved from syntenic regions that were also co-opted also for sex chromosomes in other reptiles. We showed that in male geckos, recombination is less prevalent in the proximal regions of chromosomes and is even further drastically reduced around the centromere of the neo-Y chromosome. We highlight that pre-existing recombination patterns and Robertsonian fusions can be responsible for the cessation of recombination on sex chromosomes and that such processes can be largely neutral.
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a ještěři $x genetika $7 D008116
- 650 _2
- $a pohlavní chromozomy $x genetika $7 D012730
- 650 _2
- $a chromozom Y $x genetika $7 D014998
- 650 _2
- $a pohyb buněk $7 D002465
- 650 _2
- $a rekombinace genetická $7 D011995
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Tishakova, Katerina $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia $u Novosibirsk State University, Novosibirsk, 630090, Russia
- 700 1_
- $a Romanenko, Svetlana $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia
- 700 1_
- $a Lisachova, Lada $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia $u Novosibirsk State University, Novosibirsk, 630090, Russia
- 700 1_
- $a Davletshina, Guzel $u Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia
- 700 1_
- $a Prokopov, Dmitry $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia
- 700 1_
- $a Kratochvíl, Lukáš $u Department of Ecology, Faculty of Science, Charles University, 12844, Prague, Czech Republic
- 700 1_
- $a O Brien, Patricia $u Department of Veterinary Medicine, Cambridge Resource Centre for Comparative Genomics, University of Cambridge, Cambridge, CB3 0ES, UK
- 700 1_
- $a Ferguson-Smith, Malcolm $u Department of Veterinary Medicine, Cambridge Resource Centre for Comparative Genomics, University of Cambridge, Cambridge, CB3 0ES, UK
- 700 1_
- $a Borodin, Pavel $u Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia
- 700 1_
- $a Trifonov, Vladimir $u Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Branch, Novosibirsk, 630090, Russia
- 773 0_
- $w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 13, č. 1 (2023), s. 15502
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/37726346 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20231013 $b ABA008
- 991 __
- $a 20231026110200 $b ABA008
- 999 __
- $a ok $b bmc $g 1999995 $s 1202571
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 13 $c 1 $d 15502 $e 20230919 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
- LZP __
- $a Pubmed-20231013
