• Je něco špatně v tomto záznamu ?

The Degree of Prepregnancy Vitamin D Deficiency Is Not Associated With Gestational Diabetes in Women Undergoing ART

Y. Liu, JG. Hocher, H. Chen, L. Hu, X. Zhang, S. Cai, S. Tang, F. Gong, BK. Krämer, G. Lin, B. Hocher

. 2023 ; 7 (12) : bvad140. [pub] 20231110

Status neindexováno Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23022537

CONTEXT: Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly in women undergoing assisted reproductive technology (ART). An association of GDM with vitamin D in women conceiving naturally has been described; however, studies have yielded heterogeneous results. OBJECTIVE: To analyze the association between prepregnancy total and free vitamin D and GDM incidence in women undergoing ART. METHODS: Post hoc analysis of a prospective study at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, China. Total and free vitamin D were measured 1 day before embryo transfer. The patients were screened for GDM using the oral glucose tolerance test. RESULTS: A total of 1593 women were included in the study, among whom 256 (16.1%) developed GDM. According to international guidelines for total 25-hydroxyvitamin D [25(OH)D], 47 (2.9%) patients had sufficient (≥30 ng/mL) levels, while 696 (43.7%) were insufficient (20 to <30 ng/mL) and 850 (54.4%) were deficient (<20 ng/mL). Comparing GDM and non-GDM patients, there was no significant difference in total nor free vitamin D levels (P = .340 and .849). Similarly, analysis of GDM rates by quintiles of total and free 25(OH)D showed no significant association in one-way ANOVA (P = .831 and .799). Multivariate logistic regression, considering age, BMI, and fasting glucose, also did not show a significant influence of the 2 vitamin D forms on GDM incidence (P = .266 and .123 respectively). CONCLUSION: In this relatively vitamin D deficient/insufficient ART cohort, the degree of neither total nor free vitamin D deficiency before pregnancy was associated with the occurrence of GDM.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23022537
003      
CZ-PrNML
005      
20240116163053.0
007      
ta
008      
240105s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1210/jendso/bvad140 $2 doi
035    __
$a (PubMed)38024652
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Liu, Yvonne $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Medical Faculty of Charité Universitätsmedizin Berlin, 10117 Berlin, Germany
245    14
$a The Degree of Prepregnancy Vitamin D Deficiency Is Not Associated With Gestational Diabetes in Women Undergoing ART / $c Y. Liu, JG. Hocher, H. Chen, L. Hu, X. Zhang, S. Cai, S. Tang, F. Gong, BK. Krämer, G. Lin, B. Hocher
520    9_
$a CONTEXT: Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly in women undergoing assisted reproductive technology (ART). An association of GDM with vitamin D in women conceiving naturally has been described; however, studies have yielded heterogeneous results. OBJECTIVE: To analyze the association between prepregnancy total and free vitamin D and GDM incidence in women undergoing ART. METHODS: Post hoc analysis of a prospective study at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, China. Total and free vitamin D were measured 1 day before embryo transfer. The patients were screened for GDM using the oral glucose tolerance test. RESULTS: A total of 1593 women were included in the study, among whom 256 (16.1%) developed GDM. According to international guidelines for total 25-hydroxyvitamin D [25(OH)D], 47 (2.9%) patients had sufficient (≥30 ng/mL) levels, while 696 (43.7%) were insufficient (20 to <30 ng/mL) and 850 (54.4%) were deficient (<20 ng/mL). Comparing GDM and non-GDM patients, there was no significant difference in total nor free vitamin D levels (P = .340 and .849). Similarly, analysis of GDM rates by quintiles of total and free 25(OH)D showed no significant association in one-way ANOVA (P = .831 and .799). Multivariate logistic regression, considering age, BMI, and fasting glucose, also did not show a significant influence of the 2 vitamin D forms on GDM incidence (P = .266 and .123 respectively). CONCLUSION: In this relatively vitamin D deficient/insufficient ART cohort, the degree of neither total nor free vitamin D deficiency before pregnancy was associated with the occurrence of GDM.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hocher, Johann-Georg $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Second Faculty of Medicine, Charles University, 150 06 Prague, Czech Republic
700    1_
$a Chen, Huijun $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Medical Faculty of Charité Universitätsmedizin Berlin, 10117 Berlin, Germany $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China
700    1_
$a Hu, Liang $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China $u School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410017, China $u Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha 410017, China
700    1_
$a Zhang, Xiaoli $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany $1 https://orcid.org/0000000300760854
700    1_
$a Cai, Sufen $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China $u School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410017, China
700    1_
$a Tang, Sha $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China
700    1_
$a Gong, Fei $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China $u School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410017, China $u Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha 410017, China $1 https://orcid.org/0000000298695669
700    1_
$a Krämer, Bernhard K $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha 410017, China
700    1_
$a Lin, Ge $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China $u School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410017, China $u Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha 410017, China $1 https://orcid.org/0000000238772546
700    1_
$a Hocher, Berthold $u Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, 68167 Mannheim, Germany $u Department of Clinical Science, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, China $u School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410017, China $u Institute of Medical Diagnostics, IMD, 12247 Berlin, Germany $1 https://orcid.org/0000000181430579
773    0_
$w MED00209724 $t Journal of the Endocrine Society $x 2472-1972 $g Roč. 7, č. 12 (2023), s. bvad140
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38024652 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240105 $b ABA008
991    __
$a 20240116163050 $b ABA008
999    __
$a ok $b bmc $g 2036316 $s 1208982
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 7 $c 12 $d bvad140 $e 20231110 $i 2472-1972 $m Journal of the Endocrine Society $n J Endocr Soc $x MED00209724
LZP    __
$a Pubmed-20240105

Najít záznam

Citační ukazatele

Možnosti archivace