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High RIPK3 expression is associated with a higher risk of early kidney transplant failure

A. Wahida, C. Schmaderer, M. Büttner-Herold, C. Branca, S. Donakonda, F. Haberfellner, C. Torrez, J. Schmitz, T. Schulze, T. Seibt, R. Öllinger, T. Engleitner, B. Haller, K. Steiger, R. Günthner, G. Lorenz, M. Yabal, Q. Bachmann, MC. Braunisch,...

. 2023 ; 26 (10) : 107879. [pub] 20230917

Status neindexováno Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23022683

Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury.

CECAD University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany

Clinic of General Visceral Transplantation Vascular and Thoracic Surgery University Hospital Munich Ludwig Maximilians University Munich Germany

Department 2 of Internal Medicine and Center for Molecular Medicine Cologne University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany

Department of General Visceral and Cancer Surgery University of Cologne Cologne Germany

Department of Immunology St Jude Children's Research Hospital Memphis TN USA

Department of Nephrology Klinikum rechts der Isar TUM School of Medicine Technical University of Munich Munich Germany

Department of Nephrology Transplant Center Institute for Clinical and Experimental Medicine Prague Czech Republic

Department of Nephropathology Friedrich Alexander University Erlangen Nurnberg Erlangen Germany

Department of Surgery Klinikum rechts der Isar Technical University of Munich Munich Germany

Division of Nephrology Clinic of Internal Medicine 3 University Hospital Carl Gustav Carus at the Technische Universität Dresden Dresden Germany

Division of Nephrology Department of Medicine Albert Einstein College of Medicine Bronx NY USA

Institute of AI and Informatics in Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany

Institute of Molecular Immunology and Experimental Oncology TUM School of Medicine Technical University of Munich Munich Germany

Institute of Molecular Oncology and Functional Genomics TUM School of Medicine Technical University of Munich Munich Germany

Institute of Pathology TUM School of Medicine Technical University of Munich Munich Germany

Medical Department 3 of Hematology and Oncology Klinikum rechts der Isar TUM School of Medicine Technical University of Munich Munich Germany

Nephrology Section Medical Clinic 1 University Hospital Bonn Rheinische Friedrich Wilhelm University of Bonn Bonn Germany

Nephropathology Unit Institute of Pathology Hannover Medical School Hannover Germany

Transplant Center University Hospital Munich Ludwig Maximilians University Munich Germany

Citace poskytuje Crossref.org

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$a High RIPK3 expression is associated with a higher risk of early kidney transplant failure / $c A. Wahida, C. Schmaderer, M. Büttner-Herold, C. Branca, S. Donakonda, F. Haberfellner, C. Torrez, J. Schmitz, T. Schulze, T. Seibt, R. Öllinger, T. Engleitner, B. Haller, K. Steiger, R. Günthner, G. Lorenz, M. Yabal, Q. Bachmann, MC. Braunisch, P. Moog, E. Matevossian, V. Aßfalg, S. Thorban, L. Renders, MR. Späth, RU. Müller, DL. Stippel, W. Weichert, J. Slotta-Huspenina, S. von Vietinghoff, O. Viklicky, DR. Green, R. Rad, K. Amann, A. Linkermann, JH. Bräsen, U. Heemann, S. Kemmner
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$a Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury.
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