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Eosinophils-from cradle to grave: An EAACI task force paper on new molecular insights and clinical functions of eosinophils and the clinical effects of targeted eosinophil depletion
M. Jesenak, Z. Diamant, D. Simon, E. Tufvesson, SF. Seys, M. Mukherjee, P. Lacy, S. Vijverberg, T. Slisz, A. Sediva, HU. Simon, I. Striz, J. Plevkova, J. Schwarze, R. Kosturiak, NE. Alexis, E. Untersmayr, MK. Vasakova, E. Knol, L. Koenderman
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články
PubMed
37702095
DOI
10.1111/all.15884
Knihovny.cz E-zdroje
- MeSH
- biologické markery MeSH
- eozinofily * MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
Amsterdam UMC Location University of Amsterdam Pulmonary Diseases Amsterdam The Netherlands
Department Dermatology Allergology University Medical Center Utrecht Utrecht The Netherlands
Department of Dermatology Inselspital Bern University Hospital University of Bern Bern Switzerland
Department of Medicine McMaster University Hamilton Ontario Canada
Department of Medicine University of Alberta Edmonton Alberta Canada
Department Pulmonary Diseases University Medical Center Utrecht Utrecht The Netherlands
Institute of Biochemistry Brandenburg Medical School Neuruppin Germany
Institute of Pharmacology University of Bern Bern Switzerland
Laboratory of Clinical Immunology Department of Microbiology and Immunology KU Leuven Leuven Belgium
Outpatient Clinic for Clinical Immunology and Allergology Nitra Slovak Republic
Citace poskytuje Crossref.org
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