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Je něco špatně v tomto záznamu ?
The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
S. Sharmin, I. Roos, S. Simpson-Yap, C. Malpas, MM. Sánchez, S. Ozakbas, D. Horakova, EK. Havrdova, F. Patti, R. Alroughani, G. Izquierdo, S. Eichau, C. Boz, M. Zakaria, M. Onofrj, A. Lugaresi, B. Weinstock-Guttman, A. Prat, M. Girard, P....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
37369086
DOI
10.1093/brain/awad218
Knihovny.cz E-zdroje
- MeSH
- chronicko-progresivní roztroušená skleróza * epidemiologie MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- progrese nemoci MeSH
- relabující-remitující roztroušená skleróza * epidemiologie MeSH
- roztroušená skleróza * epidemiologie diagnóza MeSH
- ultrafialové záření MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Geographical variations in the incidence and prevalence of multiple sclerosis have been reported globally. Latitude as a surrogate for exposure to ultraviolet radiation but also other lifestyle and environmental factors are regarded as drivers of this variation. No previous studies evaluated geographical variation in the risk of secondary progressive multiple sclerosis, an advanced form of multiple sclerosis that is characterized by steady accrual of irreversible disability. We evaluated differences in the risk of secondary progressive multiple sclerosis in relation to latitude and country of residence, modified by high-to-moderate efficacy immunotherapy in a geographically diverse cohort of patients with relapsing-remitting multiple sclerosis. The study included relapsing-remitting multiple sclerosis patients from the global MSBase registry with at least one recorded assessment of disability. Secondary progressive multiple sclerosis was identified as per clinician diagnosis. Sensitivity analyses used the operationalized definition of secondary progressive multiple sclerosis and the Swedish decision tree algorithm. A proportional hazards model was used to estimate the cumulative risk of secondary progressive multiple sclerosis by country of residence (latitude), adjusted for sex, age at disease onset, time from onset to relapsing-remitting phase, disability (Multiple Sclerosis Severity Score) and relapse activity at study inclusion, national multiple sclerosis prevalence, government health expenditure, and proportion of time treated with high-to-moderate efficacy disease-modifying therapy. Geographical variation in time from relapsing-remitting phase to secondary progressive phase of multiple sclerosis was modelled through a proportional hazards model with spatially correlated frailties. We included 51 126 patients (72% female) from 27 countries. The median survival time from relapsing-remitting phase to secondary progressive multiple sclerosis among all patients was 39 (95% confidence interval: 37 to 43) years. Higher latitude [median hazard ratio = 1.21, 95% credible interval (1.16, 1.26)], higher national multiple sclerosis prevalence [1.07 (1.03, 1.11)], male sex [1.30 (1.22, 1.39)], older age at onset [1.35 (1.30, 1.39)], higher disability [2.40 (2.34, 2.47)] and frequent relapses [1.18 (1.15, 1.21)] at inclusion were associated with increased hazard of secondary progressive multiple sclerosis. Higher proportion of time on high-to-moderate efficacy therapy substantially reduced the hazard of secondary progressive multiple sclerosis [0.76 (0.73, 0.79)] and reduced the effect of latitude [interaction: 0.95 (0.92, 0.99)]. At the country-level, patients in Oman, Tunisia, Iran and Canada had higher risks of secondary progressive multiple sclerosis relative to the other studied regions. Higher latitude of residence is associated with a higher probability of developing secondary progressive multiple sclerosis. High-to-moderate efficacy immunotherapy can mitigate some of this geographically co-determined risk.
Barlo Multiple Sclerosis Centre St Michael's Hospital Toronto M5B1W8 Canada
Centro Sclerosi Multipla UOC Neurologia ARNAS Garibaldi Catania 95124 Italy
CHUM MS Center Faculty of Medicine Universite de Montreal Montreal H2L 4M1 Canada
Clinic of Neurology 2 Emergency Clinical County Hospital 'Pius Brinzeu' Timisoara 300723 Romania
College of Medicine and Public Health Flinders University Adelaide 5042 Australia
Concord Repatriation General Hospital Sydney 2139 Australia
CORe Department of Medicine University of Melbourne Melbourne 3050 Australia
Département de neurologie CSSS Saint Jérôme Saint Jerome J7Z 5T3 Canada
Department NEUROFARBA University of Florence Florence 50134 Italy
Department of Medicine Sultan Qaboos University Hospital Al Khodh 123 Oman
Department of Neurology Aarhus University Hospital Arhus C 8000 Denmark
Department of Neurology and Neuro Rehabilitation AZ Alma Ziekenhuis Sijsele Damme 8340 Belgium
Department of Neurology Antwerp University Hospital Edegem 2650 Belgium
Department of Neurology Austin Health Melbourne 3084 Australia
Department of Neurology Bombay Hospital Institute of Medical Sciences Mumbai 400020 India
Department of Neurology Box Hill Hospital Melbourne 3128 Australia
Department of Neurology Centro Hospitalar Universitario de Sao Joao Porto 4200 319 Portugal
Department of Neurology Faculty of Medicine University of Debrecen Debrecen 4032 Hungary
Department of Neurology Groene Hart Hospital Gouda 2800 BB The Netherlands
Department of Neurology Hacettepe University Ankara 6100 Turkey
Department of Neurology Haydarpasa Numune Training and Research Hospital Istanbul 34668 Turkey
Department of Neurology Hospital Clinico San Carlos Madrid 28050 Spain
Department of Neurology Hospital de Galdakao Usansolo Galdakao 48660 Spain
Department of Neurology Hospital General Universitario de Alicante Alicante 3010 Spain
Department of Neurology Hospital Germans Trias i Pujol Badalona 08916 Spain
Department of Neurology Hospital Germans Trias i Pujol Badalona 8916 Spain
Department of Neurology Hospital Universitario Donostia San Sebastián 20014 Spain
Department of Neurology Kasr Al Ainy MS Research Unit Cairo 11562 Egypt
Department of Neurology McGill University Montreal H3T 1E2 Canada
Department of Neurology Medical Center Leeuwarden Leeuwarden 8934 AD The Netherlands
Department of Neurology Razi Hospital Manouba 2010 Tunisia
Department of Neurology Royal Hobart Hospital Hobart 7000 Australia
Department of Neurology Royal Victoria Hospital Belfast BT12 6BA UK
Department of Neurology South Eastern HSC Trust Belfast BT16 UK
Department of Neurology St Vincent's University Hospital Dublin D04 T6F4 Ireland
Department of Neurology St Vincents Hospital Fitzroy Melbourne 3065 Australia
Department of Neurology The Alfred Hospital Melbourne 3000 Australia
Department of Neurology Universidade Metropolitana de Santos Santos 11045 002 Brazil
Department of Neurology Universitary Hospital Ghent Ghent 9000 Belgium
Department of Neurology University Hospital Reina Sofia Cordoba 14004 Spain
Department of Neurology Westmead Hospital Sydney 2145 Australia
Department of Neuroscience Imaging and Clinical Sciences University G d'Annunzio Chieti 66013 Italy
Department of Rehabilitation CRRF 'Mons Luigi Novarese' Moncrivello 16153 Italy
Dipartimento di Scienze Biomediche e Neuromotorie Università di Bologna Bologna 40139 Italy
Division of Neurology Department of Medicine Amiri Hospital Sharq 73767 Kuwait
Faculty of Medicine 19 Mayis University Samsun 55160 Turkey
Faculty of Medicine Ain Shams University Cairo 11566 Egypt
Faculty of Medicine Dokuz Eylul University Konak Izmir 35220 Turkey
Hospital Fernandez Buenos Aires 1425 Argentina
Médecine spécialisée CISSS Chaudière Appalaches Levis G6X 0A1 Canada
Menzies Institute for Medical Research University of Tasmania Tasmania 7000 Australia
Monash Medical Centre Melbourne 3168 Australia
MS centrum Nemocnice Jihlava Jihlava 58633 Czech Republic
Multiple Sclerosis Clinic Brain and Mind Centre Sydney 2050 Australia
Multiple Sclerosis Unit Hospital Universitario Virgen Macarena Sevilla 41009 Spain
Neuro Rive Sud Hôpital Charles LeMoyne Quebec J4V 2J2 Canada
Neuroimmunology Centre Department of Neurology Royal Melbourne Hospital Melbourne 3050 Australia
Neurology Department King Fahad Specialist Hospital Dammam Khobar 31952 Saudi Arabia
Neuroscience Department Barwon Health University Hospital Geelong Geelong 3220 Australia
Ospedale Civico Lugano Lugano 6900 Switzerland
Perron Institute University of Western Australia Nedlands 6009 Australia
Rehabilitation and MS Centre Overpelt Hasselt University Hasselt 3900 Belgium
Royal Brisbane and Women's Hospital University of Queensland Brisbane 4000 Australia
Royal North Shore Hospital Sydney 2065 Australia
School of Medicine and Public Health University of Newcastle Newcastle 2305 Australia
Service de Neurologie Cliniques Universitaires Saint Luc Brussels 1200 BXL Belgium
Citace poskytuje Crossref.org
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