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Interferon signaling restrains renal cell carcinoma heterogeneity

P. Holicek, J. Fucikova, L. Galluzzi

. 2023 ; 9 (11) : 871-873. [pub] 20230830

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S., komentáře

Perzistentní odkaz   https://www.medvik.cz/link/bmc24000869

Grantová podpora
R01 CA271915 NCI NIH HHS - United States
U54 CA274291 NCI NIH HHS - United States

Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

Citace poskytuje Crossref.org

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