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An overview of the methamphetamine effect on male sexual behavior and reproductive system
L. Mihalčíková, R. Šlamberová
Language English Country Czech Republic
Document type Review, Journal Article
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- MeSH
- Behavior, Animal MeSH
- Child MeSH
- Adult MeSH
- Rats MeSH
- Humans MeSH
- Methamphetamine * adverse effects MeSH
- Genitalia MeSH
- Rats, Wistar MeSH
- Sexual Behavior MeSH
- Central Nervous System Stimulants * pharmacology MeSH
- Prenatal Exposure Delayed Effects * chemically induced MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Rats MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Drug addiction and its effect on the behavior and development of children has become a serious problem in our society. Methamphetamine (MA) is one of the most abused psychostimulants in the Czech Republic, and its abuse is rising worldwide. Previous studies have demonstrated the adverse long-term effects of maternal drug abuse on rat offspring. However, the father's contribution as a parent and donor of half of the genetic information is unclear. Previous studies of other psychostimulant drugs indicate that long-term application of MA to adult male rats may induce changes in their reproductive system and lead to changes in rat pup functional and behavioral development. Therefore, the present review aimed to investigate the effect of MA administration on reproductive toxicity and sexual behavior of adult male rats, as well as the impact of paternal MA exposure on behavioral development and locomotor activity in rat offspring.
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