-
Something wrong with this record ?
Sex-related differences in patients presenting with heart failure-related cardiogenic shock
J. Sundermeyer, C. Kellner, BN. Beer, L. Besch, A. Dettling, LF. Bertoldi, S. Blankenberg, J. Dauw, Z. Dindane, D. Eckner, I. Eitel, T. Graf, P. Horn, J. Jozwiak-Nozdrzykowska, P. Kirchhof, S. Kluge, A. Linke, U. Landmesser, P. Luedike, E....
Language English Country Germany
Document type Observational Study, Journal Article
NLK
ProQuest Central
from 2005-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-08-01 to 1 year ago
Health & Medicine (ProQuest)
from 2005-01-01 to 1 year ago
- MeSH
- Ventricular Function, Left MeSH
- Shock, Cardiogenic * diagnosis epidemiology etiology MeSH
- Humans MeSH
- Hospital Mortality MeSH
- Sex Factors MeSH
- Heart Failure * diagnosis epidemiology therapy MeSH
- Stroke Volume MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
BACKGROUND: Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is a lack of evidence on sex-related differences in HF-CS, especially regarding use of treatment and mortality risk in women vs. men. This study aimed to investigate potential differences in clinical presentation, use of treatments, and mortality between women and men with HF-CS. METHODS: In this international observational study, patients with HF-CS (without acute myocardial infarction) from 16 tertiary-care centers in five countries were enrolled between 2010 and 2021. Logistic and Cox regression models were used to assess differences in clinical presentation, use of treatments, and 30-day mortality in women vs. men with HF-CS. RESULTS: N = 1030 patients with HF-CS were analyzed, of whom 290 (28.2%) were women. Compared to men, women were more likely to be older, less likely to have a known history of heart failure or cardiovascular risk factors, and lower rates of highly depressed left ventricular ejection fraction and renal dysfunction. Nevertheless, CS severity as well as use of treatments were comparable, and female sex was not independently associated with 30-day mortality (53.0% vs. 50.8%; adjusted HR 0.94, 95% CI 0.75-1.19). CONCLUSIONS: In this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.
Cardio Center Humanitas Clinical and Research Center IRCCS Rozzano Milan Italy
Department of Cardiology AZ Sint Lucas Ghent Belgium
Department of Cardiology IKEM Prague Czech Republic
Department of Cardiology Paracelsus Medical University Nürnberg Nuremberg Germany
Department of Intensive Care Medicine University Medical Center Hamburg Eppendorf Hamburg Germany
Department of Internal Medicine 1 University Hospital Jena Jena Germany
Department of Internal Medicine 1 University Hospital Würzburg Würzburg Germany
Department of Medicine 1 University Hospital LMU Munich Munich Germany
Department of Perioperative Medicine St Bartholomew's Hospital London UK
German Center for Cardiovascular Research Partner Site Hamburg Kiel Lübeck Hamburg Germany
IRCCS Fondazione Don Gnocchi ONLUS Santa Maria Nascente Milan Italy
Medizinische Klinik 2 Kliniken Nordoberpfalz AG Weiden Germany
University Heart Center Lübeck University Hospital Schleswig Holstein Lübeck Germany
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24006552
- 003
- CZ-PrNML
- 005
- 20240423155340.0
- 007
- ta
- 008
- 240412s2024 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00392-024-02392-8 $2 doi
- 035 __
- $a (PubMed)38353681
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Sundermeyer, Jonas $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
- 245 10
- $a Sex-related differences in patients presenting with heart failure-related cardiogenic shock / $c J. Sundermeyer, C. Kellner, BN. Beer, L. Besch, A. Dettling, LF. Bertoldi, S. Blankenberg, J. Dauw, Z. Dindane, D. Eckner, I. Eitel, T. Graf, P. Horn, J. Jozwiak-Nozdrzykowska, P. Kirchhof, S. Kluge, A. Linke, U. Landmesser, P. Luedike, E. Lüsebrink, N. Majunke, N. Mangner, O. Maniuc, S. Möbius-Winkler, P. Nordbeck, M. Orban, F. Pappalardo, M. Pauschinger, M. Pazdernik, A. Proudfoot, M. Kelham, T. Rassaf, C. Scherer, PC. Schulze, RHG. Schwinger, C. Skurk, M. Sramko, G. Tavazzi, H. Thiele, L. Villanova, N. Morici, EB. Winzer, D. Westermann, B. Schrage
- 520 9_
- $a BACKGROUND: Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is a lack of evidence on sex-related differences in HF-CS, especially regarding use of treatment and mortality risk in women vs. men. This study aimed to investigate potential differences in clinical presentation, use of treatments, and mortality between women and men with HF-CS. METHODS: In this international observational study, patients with HF-CS (without acute myocardial infarction) from 16 tertiary-care centers in five countries were enrolled between 2010 and 2021. Logistic and Cox regression models were used to assess differences in clinical presentation, use of treatments, and 30-day mortality in women vs. men with HF-CS. RESULTS: N = 1030 patients with HF-CS were analyzed, of whom 290 (28.2%) were women. Compared to men, women were more likely to be older, less likely to have a known history of heart failure or cardiovascular risk factors, and lower rates of highly depressed left ventricular ejection fraction and renal dysfunction. Nevertheless, CS severity as well as use of treatments were comparable, and female sex was not independently associated with 30-day mortality (53.0% vs. 50.8%; adjusted HR 0.94, 95% CI 0.75-1.19). CONCLUSIONS: In this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a kardiogenní šok $x diagnóza $x epidemiologie $x etiologie $7 D012770
- 650 _2
- $a tepový objem $7 D013318
- 650 _2
- $a funkce levé komory srdeční $7 D016277
- 650 _2
- $a sexuální faktory $7 D012737
- 650 12
- $a srdeční selhání $x diagnóza $x epidemiologie $x terapie $7 D006333
- 650 _2
- $a mortalita v nemocnicích $7 D017052
- 655 _2
- $a pozorovací studie $7 D064888
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kellner, Caroline $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany $u Cardio Center, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy
- 700 1_
- $a Beer, Benedikt N $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
- 700 1_
- $a Besch, Lisa $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
- 700 1_
- $a Dettling, Angela $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
- 700 1_
- $a Bertoldi, Letizia Fausta $u Cardio Center, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy
- 700 1_
- $a Blankenberg, Stefan $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany $u Center for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Dauw, Jeroen $u Department of Cardiology, AZ Sint-Lucas, Ghent, Belgium
- 700 1_
- $a Dindane, Zouhir $u Department for Internal Medicine and Cardiology, Heart Centre Dresden, University Hospital, Dresden, Germany
- 700 1_
- $a Eckner, Dennis $u Department of Cardiology, Paracelsus Medical University Nürnberg, Nuremberg, Germany
- 700 1_
- $a Eitel, Ingo $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany $u University Heart Center Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany
- 700 1_
- $a Graf, Tobias $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany $u University Heart Center Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany
- 700 1_
- $a Horn, Patrick $u Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Duesseldorf, Düsseldorf, Germany
- 700 1_
- $a Jozwiak-Nozdrzykowska, Joanna $u Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany
- 700 1_
- $a Kirchhof, Paulus $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany $u Center for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Kluge, Stefan $u Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Linke, Axel $u Department for Internal Medicine and Cardiology, Heart Centre Dresden, University Hospital, Dresden, Germany
- 700 1_
- $a Landmesser, Ulf $u Department of Cardiology, Angiology and Intensive Care Medicine, DHZC Berlin, Campus Benjamin Franklin, Berlin, Germany
- 700 1_
- $a Luedike, Peter $u Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany
- 700 1_
- $a Lüsebrink, Enzo $u Department of Medicine I, University Hospital, LMU Munich, Munich, Germany
- 700 1_
- $a Majunke, Nicolas $u Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany
- 700 1_
- $a Mangner, Norman $u Department for Internal Medicine and Cardiology, Heart Centre Dresden, University Hospital, Dresden, Germany
- 700 1_
- $a Maniuc, Octavian $u Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
- 700 1_
- $a Möbius-Winkler, Sven $u Department of Internal Medicine I, University Hospital Jena, Jena, Germany
- 700 1_
- $a Nordbeck, Peter $u Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
- 700 1_
- $a Orban, Martin $u Department of Medicine I, University Hospital, LMU Munich, Munich, Germany
- 700 1_
- $a Pappalardo, Federico $u Dept Cardiothoracic and Vascular Anesthesia and Intensive Care, AO SS Antonio E Biagio E Cesare Arrigo, Alessandria, Italy
- 700 1_
- $a Pauschinger, Matthias $u Department of Cardiology, Paracelsus Medical University Nürnberg, Nuremberg, Germany
- 700 1_
- $a Pazdernik, Michal $u Department of Cardiology, IKEM, Prague, Czech Republic
- 700 1_
- $a Proudfoot, Alastair $u Department of Perioperative Medicine, St. Bartholomew's Hospital, London, UK
- 700 1_
- $a Kelham, Matthew $u Department of Perioperative Medicine, St. Bartholomew's Hospital, London, UK
- 700 1_
- $a Rassaf, Tienush $u Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany
- 700 1_
- $a Scherer, Clemens $u Department of Medicine I, University Hospital, LMU Munich, Munich, Germany
- 700 1_
- $a Schulze, Paul Christian $u Department of Internal Medicine I, University Hospital Jena, Jena, Germany
- 700 1_
- $a Schwinger, Robert H G $u Medizinische Klinik II, Kliniken Nordoberpfalz AG, Weiden, Germany
- 700 1_
- $a Skurk, Carsten $u Department of Cardiology, Angiology and Intensive Care Medicine, DHZC Berlin, Campus Benjamin Franklin, Berlin, Germany
- 700 1_
- $a Sramko, Marek $u Department of Cardiology, IKEM, Prague, Czech Republic
- 700 1_
- $a Tavazzi, Guido $u Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, Anesthesia and Intensive Care, University of Pavia Italy, Fondazione Policlinico San Matteo Hospital IRCCS, Pavia, Italy
- 700 1_
- $a Thiele, Holger $u Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Science, Leipzig, Germany
- 700 1_
- $a Villanova, Luca $u Unità Di Cure Intensive Cardiologiche and De Gasperis Cardio-Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
- 700 1_
- $a Morici, Nuccia $u IRCCS Fondazione Don Gnocchi, ONLUS, Santa Maria Nascente, Milan, Italy
- 700 1_
- $a Winzer, Ephraim B $u Department for Internal Medicine and Cardiology, Heart Centre Dresden, University Hospital, Dresden, Germany
- 700 1_
- $a Westermann, Dirk $u Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany
- 700 1_
- $a Schrage, Benedikt $u Department of Cardiology, University Heart and Vascular Center Hamburg, Martinistr. 52, 20251, Hamburg, Germany. b.schrage@uke.de $u German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. b.schrage@uke.de $1 https://orcid.org/0000000190413922
- 773 0_
- $w MED00155366 $t Clinical research in cardiology $x 1861-0692 $g Roč. 113, č. 4 (2024), s. 612-625
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38353681 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240412 $b ABA008
- 991 __
- $a 20240423155336 $b ABA008
- 999 __
- $a ok $b bmc $g 2080880 $s 1216319
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 113 $c 4 $d 612-625 $e 20240214 $i 1861-0692 $m Clinical research in cardiology $n Clin Res Cardiol $x MED00155366
- LZP __
- $a Pubmed-20240412
