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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
AH. Ou, SB. Rosenthal, M. Adli, K. Akiyama, N. Akula, M. Alda, AT. Amare, R. Ardau, B. Arias, JM. Aubry, L. Backlund, M. Bauer, BT. Baune, F. Bellivier, A. Benabarre, S. Bengesser, AK. Bhattacharjee, JM. Biernacka, P. Cervantes, GB. Chen, HC....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
R01 MH059556
NIMH NIH HHS - United States
Z01 MH002810
Intramural NIH HHS - United States
R01 MH059535
NIMH NIH HHS - United States
R01 MH059567
NIMH NIH HHS - United States
R01 MH059545
NIMH NIH HHS - United States
P01 CA089392
NCI NIH HHS - United States
R01 MH059548
NIMH NIH HHS - United States
R01 MH059534
NIMH NIH HHS - United States
R01 MH059533
NIMH NIH HHS - United States
U01 MH092758
NIMH NIH HHS - United States
K02 DA021237
NIDA NIH HHS - United States
MR/L006642/1
Medical Research Council - United Kingdom
R01 MH059553
NIMH NIH HHS - United States
R01 MH060068
NIMH NIH HHS - United States
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-04-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-04-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-04-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-04-01
- MeSH
- bipolární porucha * farmakoterapie genetika MeSH
- celogenomová asociační studie MeSH
- fokální adheze MeSH
- fosfatidylinositol-3-kinasy genetika MeSH
- lidé MeSH
- lithium * farmakologie terapeutické užití MeSH
- multiomika MeSH
- protoonkogenní proteiny c-akt genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
Bipolar Center Wiener Neustadt Austria
Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne UK
Child and Adolescent Psychiatry Research Center Stockholm Sweden
CIBER de Salud Mental ISCIII Madrid Barcelona Catalonia Spain
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Biomedicine Aarhus University Aarhus Denmark
Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden
Department of Health Sciences Research Mayo Clinic Rochester MN USA
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy
Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Pharmacology Dalhousie University Halifax NS Canada
Department of Pharmacy VA San Diego Healthcare System La Jolla CA USA
Department of Psychiatry and Behavioral Sciences Johns Hopkins University Baltimore MD USA
Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Dokkyo Medical University School of Medicine Mibu Japan
Department of Psychiatry Hokkaido University Graduate School of Medicine Sapporo Japan
Department of Psychiatry Lindner Center of Hope University of Cincinnati Mason OH USA
Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston MA USA
Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan
Department of Psychiatry University of Antioquia Medellín Medellín Colombia
Department of Psychiatry University of Calgary Calgary AB Canada
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry University of Campinas Campinas Brazil
Department of Psychiatry University of Iowa Iowa City IA USA
Department of Psychiatry University of Münster Münster Germany
Department of Psychiatry University of Naples SUN Naples Italy
Department of Psychiatry University of Toronto Toronto ON Canada
Department of Psychiatry VA San Diego Healthcare System La Jolla CA USA
Discipline of Psychiatry University of Adelaide Adelaide SA Australia
Douglas Mental Health University Institute McGill University Montreal QC Canada
Fliedner Klinik Berlin Center for Psychiatry Psychotherapy and Psychosomatic Medicine Berlin Germany
Human Genomics Research Group Department of Biomedicine University Hospital Basel Basel Switzerland
Inserm U955 Psychiatrie Translationnelle Créteil France
Institute of Epidemiology and Preventive Medicine National Taiwan University Taipei Taiwan
Laboratory for Molecular Dynamics of Mental Disorders RIKEN Brain Science Institute Saitama Japan
Ludwig Maximilians University of Munich Munich Germany
Mental Illness Research Theme Neuroscience Research Australia Sydney NSW Australia
Montreal Neurological Institute and Hospital McGill University Montreal QC Canada
Mood Disorders Center of Ottawa Ottawa ON Canada
National Institute of Mental Health Klecany Czech Republic
Neurosciences Section Department of Medicine and Surgery University of Salerno Salerno Italy
Pôle de Psychiatrie Générale Universitaire Centre Hospitalier Charles Perrens Bordeaux France
Psychiatric Genetic Unit Poznan University of Medical Sciences Poznan Poland
School of Medical Sciences University of New South Wales Sydney NSW Australia
School of Psychiatry University of New South Wales and Black Dog Institute Sydney NSW Australia
The Neuromodulation Unit McGill University Health Centre Montreal QC Canada
The University of Queensland Queensland Brain Institute Brisbane QLD Australia
Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy
Veterans Administration San Diego Healthcare System San Diego CA USA
Citace poskytuje Crossref.org
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