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Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging
D. Serra, G. Garroni, S. Cruciani, D. Coradduzza, A. Pashchenko, E. Amler, G. Pintore, R. Satta, MA. Montesu, Y. Kohl, C. Ventura, M. Maioli
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Free Medical Journals od 2000
Freely Accessible Science Journals od 2000
PubMed Central od 2007
Europe PubMed Central od 2007
ProQuest Central od 2000-03-01
Open Access Digital Library od 2000-01-01
Open Access Digital Library od 2007-01-01
Health & Medicine (ProQuest) od 2000-03-01
ROAD: Directory of Open Access Scholarly Resources od 2000
Odkazy
PubMed
38339184
DOI
10.3390/ijms25031908
Knihovny.cz E-zdroje
- MeSH
- biologické přípravky * farmakologie MeSH
- hojení ran MeSH
- kůže MeSH
- lidé MeSH
- nanovlákna * MeSH
- polyvinylalkohol MeSH
- stárnutí kůže * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study, Helichrysum italicum oil (HO) was combined with different types of electrospun nanofibers to study their protective activity on the skin and to evaluate their future application for topical treatments. In the present research, we used biodegradable polymers, including polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), which were characterized by a scanning electron microscope (SEM). All results show a positive trend in cell proliferation and viability of human skin stem cells (SSCs) and BJ fibroblasts pre-treated with combined nanofibers and then exposed to UV stress. Gene expression analysis revealed the activation of a molecular rejuvenation program in SSCs treated with functionalized nanofibers before UV exposure. Understanding the mechanisms involved in skin changes during aging allows for the future application of nanomaterials combined with HO directly to the patients.
Department of Biomedical Sciences University of Sassari Viale San Pietro 43 B 07100 Sassari Italy
Department of Medical Surgical and Experimental Sciences University of Sassari 07100 Sassari Italy
Department of Medicine Surgery and Pharmacy University of Sassari 07100 Sassari Italy
R and D Laboratory Center InoCure s r o Politických Veziu 935 13 110 00 Prague Czech Republic
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- $a Serra, Diletta $u Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy $u R&D Laboratory Center, InoCure s.r.o., Politických Veziu 935/13, 110 00 Prague, Czech Republic
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