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Parkinson ́s disease cardiovascular symptoms: A new complex functional and structural insight
V. Kincl, R. Panovský, M. Bočková, I. Rektor, ML. Mojica-Pisciotti, J. Máchal
Language English Country England, Great Britain
Document type Journal Article
Grant support
Agentura Pro Zdravotnický Výzkum České Republiky
NLK
PubMed Central
from 2024
ProQuest Central
from 2024-01-01
Health & Medicine (ProQuest)
from 2024-01-01
Wiley-Blackwell Open Access Titles
from 2024
PubMed
37889890
DOI
10.1111/ene.16110
Knihovny.cz E-resources
- MeSH
- Electrocardiography MeSH
- Atrial Fibrillation * complications MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Parkinson Disease * complications epidemiology MeSH
- Heart MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: The known impairments of the cardiovascular system in Parkinson ́s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. OBJECTIVES: To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. METHODS: Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). RESULTS: PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2 , respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2 , p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. CONCLUSIONS: This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.
Central European Institute of Technology Brno Czech Republic
Department of Neurology St Anne 's University Hospital Masaryk University Brno Czech Republic
Department of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
References provided by Crossref.org
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