-
Je něco špatně v tomto záznamu ?
EEG-vigilance regulation is associated with and predicts ketamine response in major depressive disorder
CT. Ip, M. de Bardeci, G. Kronenberg, LH. Pinborg, E. Seifritz, M. Brunovsky, S. Olbrich
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
R279-2018-1145
Lundbeckfonden (Lundbeck Foundation)
R279-2018-1145
Lundbeckfonden (Lundbeck Foundation)
19-0219
Augustinus Fonden (Augustinus Foundation)
SRG2023-00040-ICI
Universidade de Macau (University of Macau)
Free Medical Journals od 2011
Nature Open Access od 2011-04-01
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2011-04-01
Open Access Digital Library od 2011-01-01
Health & Medicine (ProQuest) od 2011-04-01
ROAD: Directory of Open Access Scholarly Resources od 2011
Odkazy
PubMed
38272875
DOI
10.1038/s41398-024-02761-x
Knihovny.cz E-zdroje
- MeSH
- bdění MeSH
- depresivní porucha unipolární * farmakoterapie MeSH
- elektroencefalografie MeSH
- ketamin * farmakologie terapeutické užití MeSH
- lidé MeSH
- mozek MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Ketamine offers promising new therapeutic options for difficult-to-treat depression. The efficacy of treatment response, including ketamine, has been intricately linked to EEG measures of vigilance. This research investigated the interplay between intravenous ketamine and alterations in brain arousal, quantified through EEG vigilance assessments in two distinct cohorts of depressed patients (original dataset: n = 24; testing dataset: n = 24). Clinical response was defined as a decrease from baseline of >33% on the Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after infusion. EEG recordings were obtained pre-, start-, end- and 24 h post- infusion, and the resting EEG was automatically scored using the Vigilance Algorithm Leipzig (VIGALL). Relative to placebo (sodium chloride 0.9%), ketamine increased the amount of low-vigilance stage B1 at end-infusion. This increase in B1 was positively related to serum concentrations of ketamine, but not to norketamine, and was independent of clinical response. In contrast, treatment responders showed a distinct EEG pattern characterized by a decrease in high-vigilance stage A1 and an increase in low-vigilance B2/3, regardless of whether placebo or ketamine had been given. Furthermore, pretreatment EEG differed between responders and non-responders with responders showing a higher percentage of stage A1 (53% vs. 21%). The logistic regression fitted on the percent of A1 stages was able to predict treatment outcomes in the testing dataset with an area under the ROC curve of 0.7. Ketamine affects EEG vigilance in a distinct pattern observed only in responders. Consequently, the percentage of pretreatment stage A1 shows significant potential as a predictive biomarker of treatment response.Clinical Trials Registration: https://www.clinicaltrialsregister.eu/ctr-search/trial/2013-000952-17/CZ Registration number: EudraCT Number: 2013-000952-17.
Center for Cognitive and Brain Sciences University of Macau Taipa Macau SAR China
Charles University 3rd Faculty of Medicine Prague Czech Republic
Epilepsy Clinic University Hospital Rigshospitalet Copenhagen Denmark
Hospital for Psychiatry Psychotherapy and Psychosomatic
National Institute of Mental Health Klecany Czech Republic
Neurobiology Research Unit University Hospital Rigshospitalet Copenhagen Denmark
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24007502
- 003
- CZ-PrNML
- 005
- 20240423160021.0
- 007
- ta
- 008
- 240412s2024 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41398-024-02761-x $2 doi
- 035 __
- $a (PubMed)38272875
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Ip, Cheng-Teng $u Center for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China $u Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
- 245 10
- $a EEG-vigilance regulation is associated with and predicts ketamine response in major depressive disorder / $c CT. Ip, M. de Bardeci, G. Kronenberg, LH. Pinborg, E. Seifritz, M. Brunovsky, S. Olbrich
- 520 9_
- $a Ketamine offers promising new therapeutic options for difficult-to-treat depression. The efficacy of treatment response, including ketamine, has been intricately linked to EEG measures of vigilance. This research investigated the interplay between intravenous ketamine and alterations in brain arousal, quantified through EEG vigilance assessments in two distinct cohorts of depressed patients (original dataset: n = 24; testing dataset: n = 24). Clinical response was defined as a decrease from baseline of >33% on the Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after infusion. EEG recordings were obtained pre-, start-, end- and 24 h post- infusion, and the resting EEG was automatically scored using the Vigilance Algorithm Leipzig (VIGALL). Relative to placebo (sodium chloride 0.9%), ketamine increased the amount of low-vigilance stage B1 at end-infusion. This increase in B1 was positively related to serum concentrations of ketamine, but not to norketamine, and was independent of clinical response. In contrast, treatment responders showed a distinct EEG pattern characterized by a decrease in high-vigilance stage A1 and an increase in low-vigilance B2/3, regardless of whether placebo or ketamine had been given. Furthermore, pretreatment EEG differed between responders and non-responders with responders showing a higher percentage of stage A1 (53% vs. 21%). The logistic regression fitted on the percent of A1 stages was able to predict treatment outcomes in the testing dataset with an area under the ROC curve of 0.7. Ketamine affects EEG vigilance in a distinct pattern observed only in responders. Consequently, the percentage of pretreatment stage A1 shows significant potential as a predictive biomarker of treatment response.Clinical Trials Registration: https://www.clinicaltrialsregister.eu/ctr-search/trial/2013-000952-17/CZ Registration number: EudraCT Number: 2013-000952-17.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mozek $7 D001921
- 650 12
- $a depresivní porucha unipolární $x farmakoterapie $7 D003865
- 650 _2
- $a elektroencefalografie $7 D004569
- 650 12
- $a ketamin $x farmakologie $x terapeutické užití $7 D007649
- 650 _2
- $a bdění $7 D014851
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a de Bardeci, Mateo $u Hospital for Psychiatry, Psychotherapy and Psychosomatic; University Zurich, Zurich, Switzerland
- 700 1_
- $a Kronenberg, Golo $u Hospital for Psychiatry, Psychotherapy and Psychosomatic; University Zurich, Zurich, Switzerland
- 700 1_
- $a Pinborg, Lars Hageman $u Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark $u Epilepsy Clinic, University Hospital Rigshospitalet, Copenhagen, Denmark
- 700 1_
- $a Seifritz, Erich $u Hospital for Psychiatry, Psychotherapy and Psychosomatic; University Zurich, Zurich, Switzerland
- 700 1_
- $a Brunovsky, Martin $u National Institute of Mental Health, Klecany, Czech Republic $u Charles University, Third Faculty of Medicine, Prague, Czech Republic $1 https://orcid.org/0000000224830848 $7 xx0070660
- 700 1_
- $a Olbrich, Sebastian $u Hospital for Psychiatry, Psychotherapy and Psychosomatic; University Zurich, Zurich, Switzerland. Sebastian.olbrich@pukzh.ch $1 https://orcid.org/0000000155574878
- 773 0_
- $w MED00177206 $t Translational psychiatry $x 2158-3188 $g Roč. 14, č. 1 (2024), s. 64
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38272875 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240412 $b ABA008
- 991 __
- $a 20240423160018 $b ABA008
- 999 __
- $a ok $b bmc $g 2081479 $s 1217269
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 14 $c 1 $d 64 $e 20240126 $i 2158-3188 $m Translational psychiatry $n Transl Psychiatry $x MED00177206
- GRA __
- $a R279-2018-1145 $p Lundbeckfonden (Lundbeck Foundation)
- GRA __
- $a R279-2018-1145 $p Lundbeckfonden (Lundbeck Foundation)
- GRA __
- $a 19-0219 $p Augustinus Fonden (Augustinus Foundation)
- GRA __
- $a SRG2023-00040-ICI $p Universidade de Macau (University of Macau)
- LZP __
- $a Pubmed-20240412