• Je něco špatně v tomto záznamu ?

Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial

T. Olsen, E. Stolt, B. Øvrebø, A. Elshorbagy, EC. Tore, S. Lee-Ødegård, H. Troensegaard, H. Johannessen, B. Doeland, AAD. Vo, AF. Dahl, K. Svendsen, M. Thoresen, H. Refsum, R. Rising, K. Barvíková, M. van Greevenbroek, V. Kožich, K. Retterstøl,...

. 2024 ; 22 (1) : 40. [pub] 20240109

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu randomizované kontrolované studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24007621

Grantová podpora
727565 Joint Programming Initiative A healthy diet for a healthy life
310475 Norges Forskningsråd
STAY 8F20013 Ministerstvo Školství, Mládeže a Tělovýchovy
VFN64165 Ministerstvo Zdravotnictví Ceské Republiky

BACKGROUND: Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. METHODS: N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. RESULTS: SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. CONCLUSION: Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www. CLINICALTRIALS: gov/study/NCT04701346.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24007621
003      
CZ-PrNML
005      
20240423160138.0
007      
ta
008      
240412s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12967-023-04833-w $2 doi
035    __
$a (PubMed)38195568
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Olsen, Thomas $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. thomas.olsen@medisin.uio.no $1 https://orcid.org/0000000318055221
245    10
$a Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial / $c T. Olsen, E. Stolt, B. Øvrebø, A. Elshorbagy, EC. Tore, S. Lee-Ødegård, H. Troensegaard, H. Johannessen, B. Doeland, AAD. Vo, AF. Dahl, K. Svendsen, M. Thoresen, H. Refsum, R. Rising, K. Barvíková, M. van Greevenbroek, V. Kožich, K. Retterstøl, KJ. Vinknes
520    9_
$a BACKGROUND: Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expression profiles in white adipose tissue (WAT), and an extensive blood biomarker profile in humans with overweight or obesity. METHODS: N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. The diets were provided in full to the participants, and both investigators and participants were blinded to the intervention. Outcome analyses were performed using linear mixed model regression adjusted for baseline values of the outcome and sex. RESULTS: SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013). Despite greater weight loss, resting metabolic rate remained similar between groups. Furthermore, SAAR decreased serum leptin, and increased ketone bodies compared to controls. In WAT, 20 genes were upregulated whereas 24 genes were downregulated (FDR < 5%) in the SAAR group compared to controls. Generally applicable gene set enrichment analyses revealed that processes associated with ribosomes were upregulated, whereas processes related to structural components were downregulated. CONCLUSION: Our study shows that SAAR leads to greater weight loss, decreased leptin and increased ketone bodies compared to controls. Further research on SAAR is needed to investigate the therapeutic potential for metabolic conditions in humans. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04701346, registered Jan 8th 2021, https://www. CLINICALTRIALS: gov/study/NCT04701346.
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    12
$a aminokyseliny sírové $7 D000603
650    _2
$a ketolátky $7 D007657
650    _2
$a leptin $7 D020738
650    _2
$a obezita $7 D009765
650    12
$a nadváha $7 D050177
650    _2
$a hmotnostní úbytek $7 D015431
655    _2
$a randomizované kontrolované studie $7 D016449
655    _2
$a časopisecké články $7 D016428
700    1_
$a Stolt, Emma $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Øvrebø, Bente $u Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Elshorbagy, Amany $u Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt $u Department of Pharmacology, University of Oxford, Oxford, UK
700    1_
$a Tore, Elena C $u Department of Internal Medicine and CARIM School of Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
700    1_
$a Lee-Ødegård, Sindre $u Department of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
700    1_
$a Troensegaard, Hannibal $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Johannessen, Hanna $u Department of Paedriatic Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
700    1_
$a Doeland, Beate $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Vo, Anna A D $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Dahl, Anja F $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Svendsen, Karianne $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway $u The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
700    1_
$a Thoresen, Magne $u Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
700    1_
$a Refsum, Helga $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway $u Department of Pharmacology, University of Oxford, Oxford, UK
700    1_
$a Rising, Russell $u D&S Consulting Services, Inc, New York, USA
700    1_
$a Barvíková, Kristýna $u Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a van Greevenbroek, Marleen $u Department of Internal Medicine and CARIM School of Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
700    1_
$a Kožich, Viktor $u Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Retterstøl, Kjetil $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway $u The Lipid Clinic, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
700    1_
$a Vinknes, Kathrine J $u Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
773    0_
$w MED00008239 $t Journal of translational medicine $x 1479-5876 $g Roč. 22, č. 1 (2024), s. 40
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38195568 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240423160134 $b ABA008
999    __
$a ok $b bmc $g 2081552 $s 1217388
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 22 $c 1 $d 40 $e 20240109 $i 1479-5876 $m Journal of translational medicine $n J Transl Med $x MED00008239
GRA    __
$a 727565 $p Joint Programming Initiative A healthy diet for a healthy life
GRA    __
$a 310475 $p Norges Forskningsråd
GRA    __
$a STAY 8F20013 $p Ministerstvo Školství, Mládeže a Tělovýchovy
GRA    __
$a VFN64165 $p Ministerstvo Zdravotnictví Ceské Republiky
LZP    __
$a Pubmed-20240412

Najít záznam

Citační ukazatele

Možnosti archivace