-
Something wrong with this record ?
Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer
O. Vít, J. Petrák
Language English Country Czech Republic
Document type Journal Article
Grant support
NU23-01-00323
Ministerstvo Školství, Mládeže a Tělovýchovy
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
ProQuest Central
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
- MeSH
- Phosphoric Diester Hydrolases * genetics chemistry metabolism MeSH
- Humans MeSH
- Lysophospholipids metabolism MeSH
- Neoplasms * MeSH
- Signal Transduction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Autotaxin, also known as ecto-nucleotide pyrophosphatase/phosphodiesterase family member 2, is a secreted glycoprotein that plays multiple roles in human physiology and cancer pathology. This protein, by converting lysophosphatidylcholine into lysophosphatidic acid, initiates a complex signalling cascade with significant biological implications. The article outlines the autotaxin gene and protein structure, expression regulation and physiological functions, but focuses mainly on the role of autotaxin in cancer development and progression. Autotaxin and lysophosphatidic acid signalling influence several aspects of cancer, including cell proliferation, migration, metastasis, therapy resistance, and interactions with the immune system. The potential of autotaxin as a diagnostic biomarker and promising drug target is also examined.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24008640
- 003
- CZ-PrNML
- 005
- 20250110125109.0
- 007
- ta
- 008
- 240509s2023 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.14712/fb2023069050149 $2 doi
- 035 __
- $a (PubMed)38583176
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Vít, Ondřej $u BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic. ondrej.vit@lf1.cuni.cz $7 xx0327709
- 245 10
- $a Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer / $c O. Vít, J. Petrák
- 520 9_
- $a Autotaxin, also known as ecto-nucleotide pyrophosphatase/phosphodiesterase family member 2, is a secreted glycoprotein that plays multiple roles in human physiology and cancer pathology. This protein, by converting lysophosphatidylcholine into lysophosphatidic acid, initiates a complex signalling cascade with significant biological implications. The article outlines the autotaxin gene and protein structure, expression regulation and physiological functions, but focuses mainly on the role of autotaxin in cancer development and progression. Autotaxin and lysophosphatidic acid signalling influence several aspects of cancer, including cell proliferation, migration, metastasis, therapy resistance, and interactions with the immune system. The potential of autotaxin as a diagnostic biomarker and promising drug target is also examined.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a fosfodiesterasy $x genetika $x chemie $x metabolismus $7 D010727
- 650 _2
- $a lysofosfolipidy $x metabolismus $7 D008246
- 650 12
- $a nádory $7 D009369
- 650 _2
- $a signální transdukce $7 D015398
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Petrák, Jiří, $u BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic $d 1969- $7 ola2006329820
- 773 0_
- $w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 69, č. 5-6 (2023), s. 149-162
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38583176 $y Pubmed
- 910 __
- $a ABA008 $b A 970 $c 89 $y p $z 0
- 990 __
- $a 20240509 $b ABA008
- 991 __
- $a 20250110125101 $b ABA008
- 999 __
- $a ok $b bmc $g 2247164 $s 1218421
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 69 $c 5-6 $d 149-162 $e - $i 0015-5500 $m Folia biologica $n Folia Biol (Praha) $x MED00011004
- GRA __
- $a NU23-01-00323 $p Ministerstvo Školství, Mládeže a Tělovýchovy
- LZP __
- $b NLK138 $a Pubmed-20240509
