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Protective Effects of Aspirin Supplemented With Quercetin in L-NAME-Induced Preeclampsia-Like Rats
J. Ding, S. Yang, D. Chen, X. Shi, Y. Zhang, L. Song, J. Zhang
Status minimal Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Aspirin adverse effects MeSH
- Rats MeSH
- Humans MeSH
- MicroRNAs * metabolism MeSH
- NG-Nitroarginine Methyl Ester pharmacology MeSH
- Placenta metabolism MeSH
- Pre-Eclampsia * chemically induced drug therapy prevention & control MeSH
- Quercetin pharmacology therapeutic use MeSH
- Pregnancy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Aspirin supplemented with quercetin was reported to enhance the therapeutic effects of aspirin in a rat model of preeclampsia. In this study, the underlying mechanisms were further explored. Preeclampsia was induced by L-NAME (50 mg/kg/day) via oral gavage from gestation day (GD)14 to GD19. Aspirin (1.5 mg/kg/day) administration was performed using aspirin mixed with rodent dough from GD0 to GD19. The administration of quercetin (2 mg/kg/day) was performed by intraperitoneal infusion from GD0 to GD19. Protein levels were evaluated using ELISA or Western blot, and microRNA (miRNA) level was evaluated by RT-PCR. Aspirin supplemented with quercetin ameliorated the increase of systolic blood pressure (SBP), proteinuria, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels, and improved the pregnancy outcomes in preeclampsia rats. Aspirin supplemented with quercetin inhibited miR-155 expression in preeclampsia rats. The decreased miR-155 level in placenta further increased the protein level of SOCS1 and inhibited the phosphorylation of p65. In this study, we demonstrated that aspirin supplemented with quercetin enhanced the effects of aspirin for the treatment of preeclampsia.
Department of Pharmacy Cangzhou Central Hospital Cangzhou Hebei China
Obstetrics Ward 1 Cangzhou Central Hospital Cangzhou Hebei China
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