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Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma
MMW. Luijten, WJ. van Weelden, RI. Lalisang, J. Bulten, K. Lindemann, HJ. van Beekhuizen, H. Trum, D. Boll, HMJ. Werner, LRCW. van Lonkhuijzen, R. Yigit, C. Krakstad, PO. Witteveen, K. Galaal, AA. van Ginkel, E. Bignotti, V. Weinberger, S....
Status not-indexed Language English Country Switzerland
Document type Journal Article
NLK
Free Medical Journals
from 2009
PubMed Central
from 2009
Europe PubMed Central
from 2009
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Open Access Digital Library
from 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2009
- Publication type
- Journal Article MeSH
BACKGROUND: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases. ER/PR-IHC can vary by tumour location and is frequently lost with tumour progression. Therefore, we explored the relationship between ER/PR-IHC expression and tumour location in EC. METHODS: Pre-treatment tumour biopsies from 6 different sites of 80 cases treated with hormonal therapy were analysed for ER/PR-IHC expression and classified into categories 0-10%, 10-50%, and >50%. The ER pathway activity score (ERPAS) was determined based on mRNA levels of ER-related target genes, reflecting the actual activity of the ER receptor. RESULTS: There was a trend towards lower PR-IHC (33% had PR > 50%) and ERPAS (27% had ERPAS > 15) in lymphogenic metastases compared to other locations (p = 0.074). Hematogenous and intra-abdominal metastases appeared to have high ER/PR-IHC and ERPAS (85% and 89% ER-IHC > 50%; 64% and 78% PR-IHC > 50%; 60% and 71% ERPAS > 15, not significant). Tumour grade and previous radiotherapy did not affect ER/PR-IHC or ERPAS. CONCLUSIONS: A trend towards lower PR-IHC and ERPAS was observed in lymphogenic sites. Verification in larger cohorts is needed to confirm these findings, which may have implications for the use of hormonal therapy in the future.
DCDC Tx B 5 5263 EM Vught The Netherlands
Department of Gynaecology Catharina Hospital 5623 EJ Eindhoven The Netherlands
Department of Gynaecology Rijnstate Hospital 6815 AD Arnhem The Netherlands
Department of Gynecology and Obstetrics Haukeland University Hospital 5009 Bergen Norway
Department of Medical Oncology University Medical Center Utrecht 3584 CX Utrecht The Netherlands
Department of Obstetrics and Gynecology University Hospital Brno 625 00 Brno Czech Republic
Department of Pathology Radboud University Medical Center 6525 GA Nijmegen The Netherlands
Division of Medicine Department of Gynecological Oncology Oslo University Hospital 0424 Oslo Norway
Faculty of Medicine Institute of Clinical Medicine University of Oslo 0372 Oslo Norway
InnoSIGN 5656 AE Eindhoven The Netherlands
Sultan Qaboos Comprehensive Cancer Center Muscat P O Box 566 PC 123 Oman
References provided by Crossref.org
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