• Je něco špatně v tomto záznamu ?

Mixed anxiety-depressive disorder in Parkinson's disease associated with worse resting state functional response to deep brain stimulation of subthalamic nucleus

P. Filip, A. Lasica, T. Uhrová, J. Mana, F. Růžička, J. Keller, K. Mueller, K. Burdová, D. Kiakou, R. Jech

. 2024 ; 10 (10) : e30698. [pub] 20240506

Status neindexováno Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24012678

BACKGROUND: Parkinson's disease (PD), even though generally perceived as a dominantly motor disorder, is associated with a wide range of non-motor symptoms, including mixed anxiety-depressive disorder (MADD). OBJECTIVES: The aim of the presented study was to determine whether deep brain stimulation (DBS) of the subthalamic nucleus (STN) brings the functional characteristics of non-motor networks closer to the condition detected in healthy population and whether pre-DBS presence of MADD in PD patients was associated with different reaction to this therapeutic modality. METHODS: Resting-state fMRI signature elicited by STN DBS activation and deactivation in 81 PD patients was compared against healthy controls, with the focus on measures of efficiency of information processing and localised subnetwork differences. RESULTS: While all the MRI metrics showed statistically significant differences between PD patients in DBS OFF condition and healthy controls, none were detected in such a comparison against DBS ON condition. Furthermore, in the post-DBS evaluation, PD patients with MADD in the pre-DBS stage showed no differences in depression scales compared to pre-DBS psychiatrically intact PD patients, but still exhibited lower DBS-related connectivity in a subnetwork encompassing anterior and posterior cingulate, dorsolateral prefrontal and medial temporal cortices. CONCLUSIONS: STN DBS improved all the metrics of interest towards the healthy state, normalising the resting-state MRI signature of PD. Furthermore, pre-DBS presence of MADD, even though clinically silent at post-DBS MRI acquisition, was associated with lower DBS effect in areas highly relevant for depression. This finding points to a possibly latent nature of post-DBS MADD, calling for caution in further follow-up of these patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24012678
003      
CZ-PrNML
005      
20240726151340.0
007      
ta
008      
240723s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.heliyon.2024.e30698 $2 doi
035    __
$a (PubMed)38778942
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Filip, Pavel $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic $u Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
245    10
$a Mixed anxiety-depressive disorder in Parkinson's disease associated with worse resting state functional response to deep brain stimulation of subthalamic nucleus / $c P. Filip, A. Lasica, T. Uhrová, J. Mana, F. Růžička, J. Keller, K. Mueller, K. Burdová, D. Kiakou, R. Jech
520    9_
$a BACKGROUND: Parkinson's disease (PD), even though generally perceived as a dominantly motor disorder, is associated with a wide range of non-motor symptoms, including mixed anxiety-depressive disorder (MADD). OBJECTIVES: The aim of the presented study was to determine whether deep brain stimulation (DBS) of the subthalamic nucleus (STN) brings the functional characteristics of non-motor networks closer to the condition detected in healthy population and whether pre-DBS presence of MADD in PD patients was associated with different reaction to this therapeutic modality. METHODS: Resting-state fMRI signature elicited by STN DBS activation and deactivation in 81 PD patients was compared against healthy controls, with the focus on measures of efficiency of information processing and localised subnetwork differences. RESULTS: While all the MRI metrics showed statistically significant differences between PD patients in DBS OFF condition and healthy controls, none were detected in such a comparison against DBS ON condition. Furthermore, in the post-DBS evaluation, PD patients with MADD in the pre-DBS stage showed no differences in depression scales compared to pre-DBS psychiatrically intact PD patients, but still exhibited lower DBS-related connectivity in a subnetwork encompassing anterior and posterior cingulate, dorsolateral prefrontal and medial temporal cortices. CONCLUSIONS: STN DBS improved all the metrics of interest towards the healthy state, normalising the resting-state MRI signature of PD. Furthermore, pre-DBS presence of MADD, even though clinically silent at post-DBS MRI acquisition, was associated with lower DBS effect in areas highly relevant for depression. This finding points to a possibly latent nature of post-DBS MADD, calling for caution in further follow-up of these patients.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Lasica, Andrej $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
700    1_
$a Uhrová, Tereza $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
700    1_
$a Mana, Josef $u Department of Science and Research, Prague College of Psychosocial Studies, Prague, Czech Republic
700    1_
$a Růžička, Filip $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
700    1_
$a Keller, Jiří $u Department of Radiology, Na Homolce Hospital, Prague, Czech Republic $u Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
700    1_
$a Mueller, Karsten $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic $u Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
700    1_
$a Burdová, Kristína $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
700    1_
$a Kiakou, Dimitra $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic $u Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
700    1_
$a Jech, Robert $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic
773    0_
$w MED00190064 $t Heliyon $x 2405-8440 $g Roč. 10, č. 10 (2024), s. e30698
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38778942 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240723 $b ABA008
991    __
$a 20240726151333 $b ABA008
999    __
$a ok $b bmc $g 2125443 $s 1224541
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 10 $c 10 $d e30698 $e 20240506 $i 2405-8440 $m Heliyon $n Heliyon $x MED00190064
LZP    __
$a Pubmed-20240723

Najít záznam

Citační ukazatele

Možnosti archivace