Researchers have studied the effects of exercise on serum methyl-arginine and vitamin D metabolites; however, the effects of exercise combined with antioxidants are not well documented. Since oxidative stress affects the metabolism of vitamin D and methyl-arginine, we hypothesised that the antioxidant coenzyme Q10 (CoQ10) might modulate exercise-induced changes. A group of twenty-eight healthy men participated in this study and were divided into two groups: an experimental group and a control group. The exercise test was performed until exhaustion, with gradually increasing intensity, before and after the 21-day CoQ10 supplementation. Blood samples were collected before, immediately after, and 3 and 24 h after exercise. CoQ10, vitamin D metabolites, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine, methylarginine, dimethylamine, arginine, citrulline, and ornithine were analysed in serum samples. CoQ10 supplementation caused a 2.76-fold increase in the concentration of serum CoQ10. Conversely, the 25(OH)D3 concentration increased after exercise only in the placebo group. ADMA increased after exercise before supplementation, but a decrease was observed in the CoQ10 supplementation group 24 h after exercise. In conclusion, our data indicate that CoQ10 supplementation modifies the effects of exercise on vitamin D and methyl-arginine metabolism, suggesting its beneficial effects. These findings contribute to the understanding of how antioxidants like CoQ10 can modulate biochemical responses to exercise, potentially offering new insights for enhancing athletic performance and recovery.

Department of Bioenergetics and Physiology of Exercise Medical University of Gdańsk 80 211 Gdańsk Poland

Department of Biological Foundations of Physical Education Faculty of Health Sciences and Physical Education Kazimierz Wielki University 85 064 Bydgoszcz Poland

Department of Biomedical Basis of Physical Education Institute of Physical Education Kazimierz Wielki University 85 064 Bydgoszcz Poland

Department of Gymnastics and Dance Gdańsk University of Physical Education and Sport 80 336 Gdańsk Poland

Department of Physical Therapy Medical University of Gdańsk 80 211 Gdańsk Poland

Faculty of Physical Education and Sport Charles University 162 52 Prague Czech Republic

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