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Improved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group
AM. Spanjaart, P. Ljungman, G. Tridello, J. Schwartz, N. Martinez-Cibrián, P. Barba, M. Kwon, L. Lopez-Corral, J. Martinez-Lopez, C. Ferra, R. Di Blasi, H. Ghesquieres, P. Mutsaers, F. Calkoen, M. Jak, J. van Doesum, JSP. Vermaat, M. van der...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- chimerické antigenní receptory imunologie MeSH
- COVID-19 * terapie imunologie mortalita MeSH
- dítě MeSH
- dospělí MeSH
- hematologické nádory * terapie mortalita imunologie MeSH
- imunoterapie adoptivní * metody škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- míra přežití MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- SARS-CoV-2 * imunologie MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa MeSH
COVID-19 has been associated with high mortality in patients treated with Chimeric Antigen Receptor (CAR) T-cell therapy for hematologic malignancies. Here, we investigated whether the outcome has improved over time with the primary objective of assessing COVID-19-attributable mortality in the Omicron period of 2022 compared to previous years. Data for this multicenter study were collected using the MED-A and COVID-19 report forms developed by the EBMT. One-hundred-eighty patients were included in the analysis, 39 diagnosed in 2020, 35 in 2021 and 106 in 2022. The median age was 58.9 years (min-max: 5.2-78.4). There was a successive decrease in COVID-19-related mortality over time (2020: 43.6%, 2021: 22.9%, 2022: 7.5%) and in multivariate analysis year of infection was the strongest predictor of survival (p = 0.0001). Comparing 2022 with 2020-2021, significantly fewer patients had lower respiratory symptoms (21.7% vs 37.8%, p = 0.01), needed oxygen support (25.5% vs 43.2%, p = 0.01), or were admitted to ICU (5.7% vs 33.8%, p = 0.0001). Although COVID-19-related mortality has decreased over time, CAR T-cell recipients remain at higher risk for complications than the general population. Consequently, vigilant monitoring for COVID-19 in patients undergoing B-cell-targeting CAR T-cell treatment is continuously recommended ensuring optimal prevention of infection and advanced state-of-the art treatment when needed.
Adult HSCT unit Northern Centre for Bone Marrow Transplantation Newcastle Tyne UK
Blood and Bone Marrow Transplantation Department University Hospital of Cardiff Cardiff UK
Cell Therapy and Transfusion Medicine Unit Azienda Ospedaliero Universitaria Careggi Firenze Italy
Cellular Therapy and immunobiology working party of EBMT
Chaim Sheba Medical Center Tel Aviv University Tel Hashomer Israel
Department of Haematology The Royal Marsden Hospital London United Kingdom
Department of Haematology University College London Hospital London UK
Department of Haematology University Hospitals Bristol and Weston NHSFT Bristol UK
Department of Hematology and Cellular Therapy IRCCS Ospedale Policlinico San Martino Genova Italy
Department of Hematology Assistance Publique Hôpitaux de Paris Hopital Saint Louis Paris France
Department of Hematology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark
Department of Hematology Erasmus MC Cancer Center Rotterdam the Netherlands
Department of Hematology Hospices Civils de Lyon Lyon Sud Hospital Pierre Bénite France
Department of Hematology Hospital Clínic Barcelona Spain
Department of Hematology Hospital Univ 12 de Octubre Complutense University CNIO Madrid Spain
Department of Hematology Hospital Universitario de La Princesa Madrid Spain
Department of Hematology Hospital Universitario de Salamanca and IBSAL Salamanca Spain
Department of Hematology Leiden University Medical Center Leiden Netherlands
Department of Hematology University Medical Center Utrecht Utrecht Netherlands
Department of Hematology Vall d'Hebron University Hospital Barcelona Spain
Department of Stem cell Transplantation University Hospital Eppendorf Hamburg Germany
Deptartment of Hematology University Hospital Gasthuisberg Leuven Belgium
European Society for Blood and Marrow Transplantation Data Office Leiden Netherlands
Hematology and BMT Unit IRCCS San Raffaele Scientific Institute Milan Italy
Princess Máxima Center for Pediatric Oncology Utrecht the Netherlands
Citace poskytuje Crossref.org
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