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Novel antagonists reveal the mechanism of PXR inhibition
R. Kamaraj, P. Pavek
Trends in pharmacological sciences.
2024 ;
45 (11) :
961-963.
[pub] 20241016
Language English Country England, Great Britain
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc25003597
- MeSH
- Humans MeSH
- Pregnane X Receptor * antagonists & inhibitors metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. Garcia-Maldonado et al. reported potent new antagonists and their co-crystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable PXR activation.
References provided by Crossref.org
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