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Young (<35 years) haploidentical versus old (≥35 years) mismatched unrelated donors and vice versa for allogeneic stem cell transplantation with post-transplant cyclophosphamide in patients with acute myeloid leukemia in first remission: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
A. Nagler, M. Labopin, R. Swoboda, D. Blaise, E. Angelucci, J. Vydra, LL. Corral, S. Bramanti, P. Chiusolo, M. Kwon, Y. Koc, M. Itäla-Remes, M. Martino, A. Kulagin, A. Busca, F. Ciceri, M. Mohty
Language English Country England, Great Britain
Document type Journal Article, Comparative Study
NLK
Free Medical Journals
from 1997 to 1 year ago
Freely Accessible Science Journals
from 1997 to 1 year ago
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Leukemia, Myeloid, Acute * therapy mortality MeSH
- Cyclophosphamide * therapeutic use MeSH
- Child MeSH
- Adult MeSH
- Transplantation, Haploidentical methods MeSH
- Transplantation, Homologous methods MeSH
- Remission Induction MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Graft vs Host Disease MeSH
- Unrelated Donors * MeSH
- Disease-Free Survival MeSH
- Transplantation Conditioning methods MeSH
- Hematopoietic Stem Cell Transplantation * methods MeSH
- Age Factors MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Geographicals
- Europe MeSH
We compared transplantation (HSCT) outcomes in AML patients undergoing HSCT with post-transplant cyclophosphamide (PTCy) in first complete remission from 1065 young (<35 years) haploidentical (Haplo) donors (yHaplo) vs. 147 old (≥35 years) mismatched unrelated donors (oMMUD) (first comparison) and from 271 young (<35 years) MMUD (yMMUD) vs. 1315 old (≥35 years) Haplo donors (oHaplo) (second comparison). Acute graft-versus-host disease (aGVHD) grades II-IV were significantly lower in the yHaplo vs. oMMUD group (HR = 0.62, p = 0.007). There were no significant differences in chronic GVHD, non-relapse mortality (NRM), relapse incidence, leukemia-free survival, overall survival, and GVHD-free and relapse-free survival. As for the second comparison, more patients in the oHaplo group had de novo AML, 86.6% vs. 81.9% in the yMMUD group (p = 0.044), while myeloablative conditioning was used more frequently in the yMMUD group, 53.3% vs. 46.8% in the oHaplo group (p = 0.049). aGVHD grades II-IV and NRM were significantly lower in the yMMUD vs. oHaplo group (HR = 0.69, p = 0.013 and HR = 0.60, p = 0.022). All other transplant outcomes did not differ. In conclusion, HSCT from young alternative donors (<35 years) results in a lower incidence of grades II-IV aGVHD. In addition, NRM is lower in HSCT from yMMUD compared to HSCT from oHaplo.
Department of Hematology Saint Antoine Hospital INSERM UMR 938 Sorbonne University Paris France
Division of Hematology Sheba Medical Center Tel Hashomer Israel
Hospital Clínico Salamanca Spain
Institute of Hematology and Blood Transfusion Prague Czech Republic
IRCCS Osspedale San Raffaele Vita Salute San Raffaele University Hematology and BMT Milano Italy
Maria Sklodowska Curie National Research Institute of Oncology Gliwice Branch Gliwice Poland
Medicana International Hospital Istanbul Istanbul Turkey
Ospedale San Raffaele s r l Milano Italy
Programme de Transplantation and Therapie Cellulaire Marseille France
RM Gorbacheva Research Institute Pavlov University Petersburg Russian Federation
References provided by Crossref.org
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