• Je něco špatně v tomto záznamu ?

Visible-Light Photoredox Catalytic Direct N-(Het)Arylation of Lactams

MF. Boselli, I. Ghosh, N. Intini, M. Fattalini, A. Puglisi, B. König, M. Benaglia

. 2025 ; 31 (18) : e202404385. [pub] 20250214

Status neindexováno Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25008183

Grantová podpora
TRR 325-444632635 Deutsche Forschungsgemeinschaft
TECHNO Ministero dell'Università e della Ricerca
MUSA - Multilayered Urban Sustainability Action NextGenerationEU, under the National Recovery and Resilience Plan (NRRP)

Lactam rings are essential structural motifs in organic chemistry, widely present in natural products and clinically important drugs, such as antibiotics and antiepileptics. Existing methods for synthesizing N-functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild and efficient photochemical approach for generating N-centered radicals, enabling straightforward N-heteroarylation of lactams. This versatile method enables the synthesis of a range of N-(het)arylated lactams and is effective even in aqueous media, facilitating the functionalization of biomolecules. Furthermore, the photochemical reaction is easily scalable under continuous flow conditions, making it highly suitable for large-scale applications.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25008183
003      
CZ-PrNML
005      
20250422095614.0
007      
ta
008      
250408s2025 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1002/chem.202404385 $2 doi
035    __
$a (PubMed)39907313
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Boselli, Monica Fiorenza $u Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy $1 https://orcid.org/0000000254182714
245    10
$a Visible-Light Photoredox Catalytic Direct N-(Het)Arylation of Lactams / $c MF. Boselli, I. Ghosh, N. Intini, M. Fattalini, A. Puglisi, B. König, M. Benaglia
520    9_
$a Lactam rings are essential structural motifs in organic chemistry, widely present in natural products and clinically important drugs, such as antibiotics and antiepileptics. Existing methods for synthesizing N-functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild and efficient photochemical approach for generating N-centered radicals, enabling straightforward N-heteroarylation of lactams. This versatile method enables the synthesis of a range of N-(het)arylated lactams and is effective even in aqueous media, facilitating the functionalization of biomolecules. Furthermore, the photochemical reaction is easily scalable under continuous flow conditions, making it highly suitable for large-scale applications.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Ghosh, Indrajit $u Fakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany $u Nanotechnology Centre, Centre for Energy and Environmental Technologies, VSB- Technical University of Ostrava, 70800, Ostrava-Poruba, Czech Republic $1 https://orcid.org/0000000251272271
700    1_
$a Intini, Niccolò $u Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy $1 https://orcid.org/0000000228072095
700    1_
$a Fattalini, Marco $u Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy $1 https://orcid.org/0009000817648563
700    1_
$a Puglisi, Alessandra $u Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy $1 https://orcid.org/0000000285818009
700    1_
$a König, Burkhard $u Fakultät für Chemie und Pharmazie, Universität Regensburg, 93053, Regensburg, Germany $1 https://orcid.org/0000000261314850 $7 ntk2013791141
700    1_
$a Benaglia, Maurizio $u Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milano, Italy $1 https://orcid.org/0000000295689642 $7 ntk20211133189
773    0_
$w MED00004916 $t Chemistry $x 1521-3765 $g Roč. 31, č. 18 (2025), s. e202404385
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39907313 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250408 $b ABA008
991    __
$a 20250422095615 $b ABA008
999    __
$a ok $b bmc $g 2306294 $s 1245258
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2025 $b 31 $c 18 $d e202404385 $e 20250214 $i 1521-3765 $m Chemistry $n Chemistry $x MED00004916
GRA    __
$a TRR 325-444632635 $p Deutsche Forschungsgemeinschaft
GRA    __
$a TECHNO $p Ministero dell'Università e della Ricerca
GRA    __
$a MUSA - Multilayered Urban Sustainability Action $p NextGenerationEU, under the National Recovery and Resilience Plan (NRRP)
LZP    __
$a Pubmed-20250408

Najít záznam

Citační ukazatele

Možnosti archivace