Background: The purpose of this study was to assess bone densitometry parameters in patients with classical and hypermobile Ehlers-Danlos syndrome (EDS) and to determine whether the hypermobile subtype increases the risk of low bone mass, which is particularly important in this patient group, since the genetic mutation responsible for this subtype is still unknown. Material and Methods: In order to conduct this study, we collaborated with the EDS society in Poland. A total of 30 females of reproductive age who were included in the study were divided into two groups: Group 1-those with classical EDS (n = 9) and Group 2-those with hypermobile EDS (n = 21). Routine laboratory test results, bone turnover markers, and densitometry parameters were evaluated and compared. Results: The study groups showed no differences in terms of densitometry parameters or markers of calcium-phosphate metabolism. A multivariate logistic analysis demonstrated no increase in the risk of low bone mass (defined as a Z-score lower than -2) in patients with hypermobile EDS (OR 0.067 [95% Cl 0.0-20.927]; p = 0.356). Conclusions: The hypermobile subtype of EDS does not increase the risk of low bone mass; there were no significant differences between patients with hypermobile EDS and those with classical EDS in terms of either densitometry parameters or markers of calcium-phosphate metabolism. Although patients with hypermobile EDS are not at a higher risk of developing low bone mineral density, they should be regularly monitored for any calcium and phosphate metabolism abnormalities.

Department of Human Epigenetics Mossakowski Medical Research Institute Polish Academy of Sciences 02 106 Warsaw Poland

Department of Internal Medicine 3rd Faculty of Medicine Charles University and Královské Vinohrady University Hospital 100 00 Prague Czech Republic

Department of Internal Medicine Endocrinology and Diabetology National Medical Institute of the Ministry of the Interior and Administration 02 507 Warsaw Poland

Students Scientific Group of the Medical University of Warsaw at the Department of Internal Medicine Endocrinology and Diabetology National Medical Institute of the Ministry of the Interior and Administration 02 091 Warsaw Poland

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