• Je něco špatně v tomto záznamu ?

Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis

T. Hospach, F. Blankenburg, A. Heinkele, K. Rücklová, P. Müller-Abt, F. Weller-Heinemann, L. Buchtala, J. Maier, J. Kümmerle-Deschner, C. Reiser, A. Janda, A. Urban, R. Berendes, A. Skrabl-Baumgartner, J. Brunner, R. Trauzeddel, JP. Haas, A....

. 2025 ; 7 (1) : e11799. [pub] -

Status neindexováno Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25008732

OBJECTIVE: Pulmonary involvement in chronic nonbacterial osteomyelitis (CNO) is rare. Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered. METHODS: Based on a survey shared among centers participating in the Kerndokumentation Deutsches Rheumaforschungszentrum (Germany), this study investigated clinical and imaging presentations, demographic features, treatment response and outcomes of pulmonary involvement in CNO (pCNO). Magnetic resonance imaging and computed tomography images were read centrally by an experienced pediatric radiologist. RESULTS: Twenty-two patients with pCNO were included in this study. Among patients with CNO, pulmonary involvement was more common in girls (91% vs 62.8%, P = 0.006) and patients with multifocal bone lesions (95% vs 65%, P <0.001) but was not associated with systemic inflammation or additional organ involvement. Forty-two pulmonary lesions were counted with a median of two per patient (two to six). They displayed a median size of 1.8 cm (0.3-4.0 cm) and followed mono- (40%) and oligo-focal (60%) patterns representing consolidations or nodules, abutting the pleura in 50%. Although prominent hilar lymph nodes were present (in 19% of patients), no pathologic enlargement (>1 cm) was seen. When available (3 of 22 patients), histology revealed granulomatous inflammation with lymphocyte infiltration. Development and courses of pCNO did not associate with treatments chosen. Complete remission was reported in 60% of patients, partial remission in 20%. CONCLUSION: pCNO is usually asymptomatic. Although more common in girls and patients with multifocal CNO, pCNO is not associated with systemic parameters of inflammation or specific organ involvement. Prognosis of pCNO is favorable, and most lesions resolve over time. Thus, a careful watch-and-wait strategy may be appropriate.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25008732
003      
CZ-PrNML
005      
20250422095737.0
007      
ta
008      
250408s2025 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/acr2.11799 $2 doi
035    __
$a (PubMed)39876070
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hospach, Toni $u Olgahospital, Klinikum Stuttgart, Germany $1 https://orcid.org/0000000156569165
245    10
$a Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis / $c T. Hospach, F. Blankenburg, A. Heinkele, K. Rücklová, P. Müller-Abt, F. Weller-Heinemann, L. Buchtala, J. Maier, J. Kümmerle-Deschner, C. Reiser, A. Janda, A. Urban, R. Berendes, A. Skrabl-Baumgartner, J. Brunner, R. Trauzeddel, JP. Haas, A. Holl-Wieden, H. Morbach, A. Schnabel, N. Brück, G. Hahn, W. Emminger, I. Valent, R. Borchers, C. Klemann, I. Tsiflikas, J. Klotsche, K. Minden, CM. Hedrich, T. von Kalle
520    9_
$a OBJECTIVE: Pulmonary involvement in chronic nonbacterial osteomyelitis (CNO) is rare. Limited awareness results in diagnostic challenges, especially because malignancy or infection needs to be considered. METHODS: Based on a survey shared among centers participating in the Kerndokumentation Deutsches Rheumaforschungszentrum (Germany), this study investigated clinical and imaging presentations, demographic features, treatment response and outcomes of pulmonary involvement in CNO (pCNO). Magnetic resonance imaging and computed tomography images were read centrally by an experienced pediatric radiologist. RESULTS: Twenty-two patients with pCNO were included in this study. Among patients with CNO, pulmonary involvement was more common in girls (91% vs 62.8%, P = 0.006) and patients with multifocal bone lesions (95% vs 65%, P <0.001) but was not associated with systemic inflammation or additional organ involvement. Forty-two pulmonary lesions were counted with a median of two per patient (two to six). They displayed a median size of 1.8 cm (0.3-4.0 cm) and followed mono- (40%) and oligo-focal (60%) patterns representing consolidations or nodules, abutting the pleura in 50%. Although prominent hilar lymph nodes were present (in 19% of patients), no pathologic enlargement (>1 cm) was seen. When available (3 of 22 patients), histology revealed granulomatous inflammation with lymphocyte infiltration. Development and courses of pCNO did not associate with treatments chosen. Complete remission was reported in 60% of patients, partial remission in 20%. CONCLUSION: pCNO is usually asymptomatic. Although more common in girls and patients with multifocal CNO, pCNO is not associated with systemic parameters of inflammation or specific organ involvement. Prognosis of pCNO is favorable, and most lesions resolve over time. Thus, a careful watch-and-wait strategy may be appropriate.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Blankenburg, Friederike $u Olgahospital, Klinikum Stuttgart, Germany
700    1_
$a Heinkele, Anita $u Olgahospital, Klinikum Stuttgart, Germany
700    1_
$a Rücklová, Kristina $u Olgahospital, Klinikum Stuttgart, Germany, and Charles University, Prague, Czech Republic
700    1_
$a Müller-Abt, Peter $u Olgahospital, Klinikum Stuttgart, Germany
700    1_
$a Weller-Heinemann, Frank $u Prof.-Hess-Kinderklinik, Bremen, Germany
700    1_
$a Buchtala, Laura $u Prof.-Hess-Kinderklinik, Bremen, Germany
700    1_
$a Maier, Jan $u Children Medical Practice, Leinfelden-Echterdingen, Germany
700    1_
$a Kümmerle-Deschner, Jasmin $u University of Tübingen, Tübingen, Germany
700    1_
$a Reiser, Christiane $u University of Tübingen, Tübingen, Germany, and Landeskrankenhaus Bregenz, Bregenz, Austria $1 https://orcid.org/0000000168172798
700    1_
$a Janda, Ales $u University Medical Center, Ulm University, Ulm, Germany
700    1_
$a Urban, Andreas $u Klinikum St Marien, Amberg, Germany
700    1_
$a Berendes, Reiner $u Center for Pediatric Rheumatology, Landshut, Germany
700    1_
$a Skrabl-Baumgartner, Andrea $u Medical University Graz, Graz, Austria
700    1_
$a Brunner, Jürgen $u Medical University of Innsbruck, Innsbruck, Austria, and Danube Private University, Krems, Austria
700    1_
$a Trauzeddel, Ralf $u Helios Klinikum Berlin-Buch, Berlin, Germany
700    1_
$a Haas, Johannes Peter $u German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany
700    1_
$a Holl-Wieden, Annette $u University of Wuerzburg, Wuerzburg, Germany
700    1_
$a Morbach, Henner $u University of Wuerzburg, Wuerzburg, Germany $1 https://orcid.org/000000025819726X
700    1_
$a Schnabel, Anja $u Technische Universität, Dresden, Germany
700    1_
$a Brück, Normi $u Technische Universität, Dresden, Germany
700    1_
$a Hahn, Gabriele $u Technische Universität, Dresden, Germany
700    1_
$a Emminger, Wolfgang $u University of Vienna, Vienna, Austria
700    1_
$a Valent, Isabella $u University of Vienna, Vienna, Austria
700    1_
$a Borchers, Regine $u University of Augsburg, Augsburg, Germany
700    1_
$a Klemann, Christian $u University of Leipzig, Leipzig, Germany
700    1_
$a Tsiflikas, Ilias $u University of Tübingen, Tübingen, Germany
700    1_
$a Klotsche, Jens $u Charité Universitätsmedizin Berlin, Berlin, Germany $1 https://orcid.org/0000000229545755
700    1_
$a Minden, Kirsten $u Charité Universitätsmedizin Berlin and Rheuma-Forschungszentrum Berlin, Berlin, Germany $1 https://orcid.org/0000000327750111
700    1_
$a Hedrich, Christian M $u University of Liverpool and Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom
700    1_
$a von Kalle, Thekla $u Olgahospital, Klinikum Stuttgart, Germany
773    0_
$w MED00203195 $t ACR open rheumatology $x 2578-5745 $g Roč. 7, č. 1 (2025), s. e11799
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39876070 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250408 $b ABA008
991    __
$a 20250422095738 $b ABA008
999    __
$a ok $b bmc $g 2306466 $s 1245807
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2025 $b 7 $c 1 $d e11799 $e - $i 2578-5745 $m ACR open rheumatology $n ACR Open Rheumatol $x MED00203195
LZP    __
$a Pubmed-20250408

Najít záznam

Citační ukazatele

Možnosti archivace