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Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer
K. Vokacova, A. Landecka, S. Selvi, J. Horak, V. Novosadova, K. Manakova, M. Levy, V. Vymetalkova
Language English Country England, Great Britain
Document type Journal Article
- MeSH
- Drug Resistance, Neoplasm * genetics MeSH
- Fluorouracil * therapeutic use pharmacology MeSH
- Middle Aged MeSH
- Humans MeSH
- MicroRNAs * genetics blood MeSH
- Biomarkers, Tumor genetics blood MeSH
- Colonic Neoplasms * genetics drug therapy blood pathology MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer. The aim of the present study was to investigate whether these miRNAs can also reflect the disease course of patients with colon cancer (CC). Further, we focused on a deeper understanding of their involvement in 5-fluorouracil (5-FU) chemoresistance development.
1st Medical Faculty Charles University Prague 142 20 Czech Republic
3rd Faculty of Medicine Charles University Ruska 87 Prague 10000 Czech Republic
References provided by Crossref.org
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