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Genome sequences of four Ixodes species expands understanding of tick evolution

A. Cerqueira de Araujo, B. Noel, A. Bretaudeau, K. Labadie, M. Boudet, N. Tadrent, B. Istace, S. Kritli, C. Cruaud, R. Olaso, JF. Deleuze, MJ. Voordouw, C. Hervet, O. Plantard, A. Zamoto-Niikura, T. Chertemps, M. Maïbèche, F. Hilliou, G. Le Goff,...

. 2025 ; 23 (1) : 17. [pub] 20250121

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25010217

BACKGROUND: Ticks, hematophagous Acari, pose a significant threat by transmitting various pathogens to their vertebrate hosts during feeding. Despite advances in tick genomics, high-quality genomes were lacking until recently, particularly in the genus Ixodes, which includes the main vectors of Lyme disease. RESULTS: Here, we present the genome sequences of four tick species, derived from a single female individual, with a particular focus on the European species Ixodes ricinus, achieving a chromosome-level assembly. Additionally, draft assemblies were generated for the three other Ixodes species, I. persulcatus, I. pacificus, and I. hexagonus. The quality of the four genomes and extensive annotation of several important gene families have allowed us to study the evolution of gene repertoires at the level of the genus Ixodes and of the tick group. We have determined gene families that have undergone major amplifications during the evolution of ticks, while an expression atlas obtained for I. ricinus reveals striking patterns of specialization both between and within gene families. Notably, several gene family amplifications are associated with a proliferation of single-exon genes-most strikingly for fatty acid elongases and sulfotransferases. CONCLUSIONS: The integration of our data with existing genomes establishes a solid framework for the study of gene evolution, improving our understanding of tick biology. In addition, our work lays the foundations for applied research and innovative control targeting these organisms.

ANSES INRAE Ecole Nationale Vétérinaire d'Alfort UMR BIPAR Laboratoire de Santé Animale 22 Rue Pierre Et Marie Curie Maisons Alfort France

Centre National de Recherche en Génomique Humaine Institut de Biologie François Jacob CEA Université Paris Saclay Evry France

Department of Medical Biology Faculty of Science University of South Bohemia in České Budějovice Branišovská 31 37005 České Budějovice Czech Republic

Department of Veterinary Microbiology Western College of Veterinary Medicine University of Saskatchewan Saskatoon Canada

Dpto de Genética Facultad de Ciencias Universidad de Granada Campus de Fuentenueva S N 18071 Granada Spain

Génomique Métabolique Genoscope Institut François Jacob CEA CNRS Univ Evry Université Paris Saclay 91057 Evry France

Genoscope Institut François Jacob CEA CNRS Univ Evry Université Paris Saclay 91057 Evry France

IGEPP INRAE Institut Agro BIPAA University of Rennes Rennes France

INRAE Université de Tours UMR1282 Infectiologie Et Santé Publique 37380 Nouzilly France

Institut d'Ecologie Et Des Sciences de L'Environnement de Paris Sorbonne Université INRAE CNRS IRD UPEC Paris France

Institute of Molecular Biology and Biotechnology Foundation for Research and Technology Hellas N Plastira 100 70013 Heraklion Crete Greece

Institute of Parasitology Biology Centre Czech Academy of Sciences Branišovská 1160 31 37005 České Budějovice Czech Republic

Lab de Bioinformática Centro de Investigación Biomédica PTS Instituto de Biotecnología Avda del Conocimiento S N 18100 Granada Spain

Oniris INRAE BIOEPAR 44300 Nantes France

Research Center for Biosafety Laboratory Animal and Pathogen Bank National Institute of Infectious Diseases Tokyo Japan

Université Côte d'Azur INRAE CNRS ISA 06903 Sophia Antipolis France

University of Rennes INRIA CNRS IRISA Rennes France

Citace poskytuje Crossref.org

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