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Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus
L. Furian, U. Heemann, M. Bengtsson, O. Bestard, I. Binet, GA. Böhmig, J. Boletis, D. Briggs, FHJ. Claas, L. Couzi, E. Cozzi, M. Crespo, APJ. De Vries, F. Diekmann, M. Durlik, D. Glotz, I. Helantera, A. Jackson, SC. Jordan, D. Kuypers, C....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2022
PubMed Central
od 2022
Medline Complete (EBSCOhost)
od 2004-05-01
ROAD: Directory of Open Access Scholarly Resources
od 1988
PubMed
39867871
DOI
10.3389/ti.2024.13886
Knihovny.cz E-zdroje
- MeSH
- dárci tkání * MeSH
- delfská metoda * MeSH
- desenzibilizace imunologická * metody MeSH
- HLA antigeny * imunologie MeSH
- imunoglobulin G MeSH
- konsensus * MeSH
- lidé MeSH
- rejekce štěpu prevence a kontrola imunologie MeSH
- transplantace ledvin * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor-recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically. Hence, this Delphi methodology was used to reach a consensus from a multi-disciplinary team (MDT) of experts from 15 countries on the management of HS patients undergoing imlifidase HLAi from a deceased donor (DD) KTx. This Delphi consensus provides clinical practice guidance on the use of imlifidase in the end-to-end management of HS patients undergoing an HLAi DD KTx and supports centers in the development of guidelines for the utilization and integration of imlifidase into clinical practice.
Abteilung für Nephrologie Klinikum Rechts der Isar Technische Universität München Munich Germany
Clinic of Nephrology and Transplantation Medicine Cantonal Hospital St Gallen St Gallen Switzerland
Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden
Department of Immunology Leiden University Medical Center Leiden Netherlands
Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium
Department of Nephrology and Kidney Transplantation Hospital Clínic Barcelona Barcelona Spain
Department of Nephrology and Renal Transplantation Saint Louis Hospital in Paris Paris France
Department of Nephrology and Renal Transplantation University Hospitals Leuven Leuven Belgium
Department of Nephrology Institute for Clinical and Experimental Medicine Prague Czechia
Department of Nephrology of Technische Universität München München Munich Germany
Department of Nephrology UZ Antwerpen Antwerpen Belgium
Department of Surgery Duke University Durham NC United States
Immunology Department and National Tissue Typing Center G Gennimatas Hospital Athens Greece
Laboratory of Immunology and Histocompatibility Hôpital Saint Louis APHP Paris Paris France
Medical University of Vienna Vienna Austria
Nephrology and Kidney Transplant Department Vall d'Hebron University Hospital Barcelona Spain
Uppsala University Department of Surgical Sciences Section of Transplant Surgery Uppsala Sweden
Citace poskytuje Crossref.org
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