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Unraveling the Role of the Tumor Extracellular Matrix to Inform Nanoparticle Design for Nanomedicine

M. Cassani, S. Fernandes, S. Pagliari, F. Cavalieri, F. Caruso, G. Forte

. 2025 ; 12 (2) : e2409898. [pub] 20241204

Language English Country Germany

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc25010451

Grant support
800924 AIRC-Marie Skłodowska-Curie Grant Agreement No
CZ.02.1.01/0.0/0.0/16_019/0000868 European Regional Development Fund-Project ENOCH
CZ.02.1.01/0.0/0.0/15_003/0000492 European Social Fund and European Regional Development Fund-Project MAGNET
101031744 H2020-MSCA-IF-GF "MecHA-Nano" Grant Agreement No
NU23J-08-00035 Ministry of Health of the Czech Republic
GNT2016732 National Health and Medical Research Council
RE/18/2/34213 King's College BHF Centre of Research Excellence
87223 H2020 Marie Skłodowska-Curie RISE "PEPSA-MATE"

The extracellular matrix (ECM)-and its mechanobiology-regulates key cellular functions that drive tumor growth and development. Accordingly, mechanotherapy is emerging as an effective approach to treat fibrotic diseases such as cancer. Through restoring the ECM to healthy-like conditions, this treatment aims to improve tissue perfusion, facilitating the delivery of chemotherapies. In particular, the manipulation of ECM is gaining interest as a valuable strategy for developing innovative treatments based on nanoparticles (NPs). However, further progress is required; for instance, it is known that the presence of a dense ECM, which hampers the penetration of NPs, primarily impacts the efficacy of nanomedicines. Furthermore, most 2D in vitro studies fail to recapitulate the physiological deposition of matrix components. To address these issues, a comprehensive understanding of the interactions between the ECM and NPs is needed. This review focuses on the main features of the ECM and its complex interplay with NPs. Recent advances in mechanotherapy are discussed and insights are offered into how its combination with nanomedicine can help improve nanomaterials design and advance their clinical translation.

References provided by Crossref.org

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