-
Je něco špatně v tomto záznamu ?
Hormonal biomarkers remain prognostically relevant within the molecular subgroups in endometrial cancer
SW. Vrede, WJ. Van Weelden, J. Bulten, CB. Gilks, S. Teerenstra, J. Huvila, X. Matias-Guiu, A. Gil-Moreno, J. Asberger, S. Sweegers, LJM. van der Putten, HVN. Küsters-Vandevelde, C. Reijnen, E. Colas, J. Hausnerová, V. Weinberger, MPLM. Snijders,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie
- MeSH
- dospělí MeSH
- imunohistochemie MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery * metabolismus genetika MeSH
- nádorový supresorový protein p53 metabolismus genetika MeSH
- nádory endometria * metabolismus patologie genetika mortalita MeSH
- prognóza MeSH
- receptory pro estrogeny * metabolismus biosyntéza MeSH
- receptory progesteronu * metabolismus biosyntéza MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: The prognostic relevance of hormonal biomarkers in endometrial cancer (EC) has been well-established. A refined three-tiered risk model for estrogen receptor (ER)/progesterone receptor (PR) expression was shown to improve prognostication. This has not been evaluated in relation to the molecular subgroups. This study aimed to evaluate the ER/PR expression within the molecular subgroups in EC. METHODS: A retrospective multicenter cohort study was performed and data from the European Network for Individualized Treatment centers and Vancouver, Canada were used. ER/PR immunohistochemical expression was grouped as: ER/PR 0-10 %, 20-80 % or 90-100 %. Molecular subgroups were determined with full next-generation sequencing or combined with immunohistochemistry: POLEmut, mismatch repair deficient (MMRd), p53mut and no-specific molecular profile (NSMP). RESULTS: A total of 739 patients were included (median follow-up 5.0 years). Tumors were classified as POLEmut in 9.1 %(N = 67), MMRd in 27.6 %(N = 204), p53mut in 20.8 %(N = 154) and NSMP in 42.5 %(N = 314). Among all molecular subgroups, patients with ER/PR 90-100 % expression revealed the best disease-specific survival (DSS). Within p53mut, PR 90-100 % expression showed a 5-year DSS of 100.0 %. ER expression is prognostic more relevant in MMRd and NSMP tumors while PR expression in p53mut and NSMP tumors. Across all molecular subgroups, PR 0-10 %, p53mut, lympho-vascular space invasion and FIGO stage III-IV remained independently prognostic for reduced DSS Whereas PR 90-100 % and POLEmut remained independently prognostic for improved DSS. CONCLUSION: We demonstrated that ER/PR expression remain prognostically relevant within the molecular subgroups, and that a three-tiered cutoff refines prognostication. These data support incorporating routine evaluation of ER/PR expression in clinical practice.
Department of Health Evidence Radboud university medical center Nijmegen the Netherlands
Department of Obstetrics and Gynecology Canisius Wilhelmina Hospital Nijmegen the Netherlands
Department of Obstetrics and Gynecology Medical Center University of Freiburg Freiburg Germany
Department of Obstetrics and Gynecology Radboud University Medical Center Nijmegen the Netherlands
Department of Pathology Canisius Wilhelmina Hospital Nijmegen the Netherlands
Department of Pathology Radboud university Medical Center Nijmegen the Netherlands
Department of Pathology University Hospital in Brno and Masaryk University Brno Czech Republic
Department of Pathology University of Turku Turku Finland
Department of Radiation Oncology Radboud University Medical Center Nijmegen the Netherlands
Gynecological Department Vall Hebron University Hospital CIBERONC Barcelona Spain
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25010477
- 003
- CZ-PrNML
- 005
- 20250429134626.0
- 007
- ta
- 008
- 250415e20241107xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ygyno.2024.10.028 $2 doi
- 035 __
- $a (PubMed)39515079
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Vrede, Stephanie W $u Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands. Electronic address: stephanie.vrede@radboudumc.nl
- 245 10
- $a Hormonal biomarkers remain prognostically relevant within the molecular subgroups in endometrial cancer / $c SW. Vrede, WJ. Van Weelden, J. Bulten, CB. Gilks, S. Teerenstra, J. Huvila, X. Matias-Guiu, A. Gil-Moreno, J. Asberger, S. Sweegers, LJM. van der Putten, HVN. Küsters-Vandevelde, C. Reijnen, E. Colas, J. Hausnerová, V. Weinberger, MPLM. Snijders, P. Vinklerova, A. Ravaggi, F. Odicino, E. Bignotti, JN. McAlpine, R. Kruitwagen, JMA. Pijnenborg
- 520 9_
- $a OBJECTIVE: The prognostic relevance of hormonal biomarkers in endometrial cancer (EC) has been well-established. A refined three-tiered risk model for estrogen receptor (ER)/progesterone receptor (PR) expression was shown to improve prognostication. This has not been evaluated in relation to the molecular subgroups. This study aimed to evaluate the ER/PR expression within the molecular subgroups in EC. METHODS: A retrospective multicenter cohort study was performed and data from the European Network for Individualized Treatment centers and Vancouver, Canada were used. ER/PR immunohistochemical expression was grouped as: ER/PR 0-10 %, 20-80 % or 90-100 %. Molecular subgroups were determined with full next-generation sequencing or combined with immunohistochemistry: POLEmut, mismatch repair deficient (MMRd), p53mut and no-specific molecular profile (NSMP). RESULTS: A total of 739 patients were included (median follow-up 5.0 years). Tumors were classified as POLEmut in 9.1 %(N = 67), MMRd in 27.6 %(N = 204), p53mut in 20.8 %(N = 154) and NSMP in 42.5 %(N = 314). Among all molecular subgroups, patients with ER/PR 90-100 % expression revealed the best disease-specific survival (DSS). Within p53mut, PR 90-100 % expression showed a 5-year DSS of 100.0 %. ER expression is prognostic more relevant in MMRd and NSMP tumors while PR expression in p53mut and NSMP tumors. Across all molecular subgroups, PR 0-10 %, p53mut, lympho-vascular space invasion and FIGO stage III-IV remained independently prognostic for reduced DSS Whereas PR 90-100 % and POLEmut remained independently prognostic for improved DSS. CONCLUSION: We demonstrated that ER/PR expression remain prognostically relevant within the molecular subgroups, and that a three-tiered cutoff refines prognostication. These data support incorporating routine evaluation of ER/PR expression in clinical practice.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a nádory endometria $x metabolismus $x patologie $x genetika $x mortalita $7 D016889
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a receptory progesteronu $x metabolismus $x biosyntéza $7 D011980
- 650 12
- $a receptory pro estrogeny $x metabolismus $x biosyntéza $7 D011960
- 650 _2
- $a senioři $7 D000368
- 650 12
- $a nádorové biomarkery $x metabolismus $x genetika $7 D014408
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádorový supresorový protein p53 $x metabolismus $x genetika $7 D016159
- 650 _2
- $a imunohistochemie $7 D007150
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Van Weelden, Willem Jan $u Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands
- 700 1_
- $a Bulten, Johan $u Department of Pathology, Radboud university Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a Gilks, C Blake $u Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, Vancouver, Canada
- 700 1_
- $a Teerenstra, Steven $u Department of Health Evidence, Radboud university medical center, Nijmegen, the Netherlands
- 700 1_
- $a Huvila, Jutta $u Department of Pathology, University of Turku, Turku, Finland
- 700 1_
- $a Matias-Guiu, Xavier $u Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC, Lleida, Spain
- 700 1_
- $a Gil-Moreno, Antonio $u Gynecological Department, Vall Hebron University Hospital, CIBERONC, Barcelona, Spain; Biomedical Research Group in Gynecology, Vall Hebron Institute of Research, Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain
- 700 1_
- $a Asberger, Jasmin $u Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, Freiburg, Germany
- 700 1_
- $a Sweegers, Sanne $u Department of Pathology, Radboud university Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a van der Putten, Louis J M $u Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a Küsters-Vandevelde, Heidi V N $u Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands
- 700 1_
- $a Reijnen, Casper $u Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a Colas, Eva $u Biomedical Research Group in Gynecology, Vall Hebron Institute of Research, Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain
- 700 1_
- $a Hausnerová, Jitka $u Department of Pathology, University Hospital in Brno and Masaryk University, Brno, Czech Republic
- 700 1_
- $a Weinberger, Vit $u Department of Obstetrics and Gynecology, University Hospital Brno and Masaryk University, Brno, Czech Republic
- 700 1_
- $a Snijders, Marc P L M $u Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands
- 700 1_
- $a Vinklerova, Petra $u Department of Obstetrics and Gynecology, University Hospital Brno and Masaryk University, Brno, Czech Republic
- 700 1_
- $a Ravaggi, Antonella $u Angelo Nocivelli' Institute of Molecular Medicine, Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy
- 700 1_
- $a Odicino, Franco $u Angelo Nocivelli' Institute of Molecular Medicine, Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy
- 700 1_
- $a Bignotti, Eliana $u Angelo Nocivelli' Institute of Molecular Medicine, Division of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy
- 700 1_
- $a McAlpine, Jessica N $u Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, Canada
- 700 1_
- $a Kruitwagen, Roy $u Department of Obstetrics and Gynecology and GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a Pijnenborg, Johanna M A $u Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands
- 773 0_
- $w MED00001958 $t Gynecologic oncology $x 1095-6859 $g Roč. 192 (20241107), s. 15-23
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39515079 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250415 $b ABA008
- 991 __
- $a 20250429134621 $b ABA008
- 999 __
- $a ok $b bmc $g 2311687 $s 1247558
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 192 $c - $d 15-23 $e 20241107 $i 1095-6859 $m Gynecologic oncology $n Gynecol Oncol $x MED00001958
- LZP __
- $a Pubmed-20250415
