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Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists
E. Papini, R. Attanasio, M. Žarković, EV. Nagy, R. Negro, P. Perros, JC. Galofré, CA. Cohen, E. Akarsu, M. Alevizaki, G. Ayvaz, T. Bednarczuk, BN. Beleslin, E. Berta, M. Bodor, AM. Borissova, M. Boyanov, C. Buffet, MC. Burlacu, J. Ćirić, JJ....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- dospělí MeSH
- endokrinologové statistika a číselné údaje MeSH
- hormony štítné žlázy * terapeutické užití MeSH
- lékařská praxe - způsoby provádění statistika a číselné údaje MeSH
- lidé středního věku MeSH
- lidé MeSH
- průzkumy a dotazníky MeSH
- struma * epidemiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. PURPOSE: To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. METHODS: Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. RESULTS: The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41-50, 51-60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03-1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33-0.48), Northern Europe (OR 0.28, 95% CI 0.22-0.36) and Western Asia (OR 0.16, 95% CI 0.11-0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. CONCLUSIONS: Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
Belarusian State Medical University Department of Endocrinology Minsk Republic of Belarus
Cabinet Médical 2 rue Bellefontaine Lausanne Switzerland
Clinic of Endocrinology and Metabolism University Hospital Alexandrovska
Department of Endocrinology and Diabetes Centre Hellenic Red Cross Hospital Athens Greece
Department of Endocrinology and Metabolism Regina Apostolorum Hospital Albano Laziale Rome Italy
Department of Endocrinology Carol Davila University of Medicine and Pharmacy Bucharest Romania
Department of Endocrinology Clínica Universidad de Navarra Pamplona Spain
Department of Endocrinology Diabetes and Metabolism
Department of Endocrinology Odense University Hospital Odense Denmark
Department of Endocrinology Skåne University Hospital Malmö Sweden
Department of Endocrinology Tampere University Hospital Tampere Finland
Department of Internal Medicine and Endocrinology Medical University of Warsaw Warsaw Poland
Department of Internal Medicine Medical University Sofia Sofia Bulgaria
Department of Medicine Universidad Autónoma de Madrid Madrid Spain
Department of Surgery Tampere University Hospital Tampere Finland
Diabetes and Endocrinology Section Beacon Hospital Dublin Ireland
Division of Endocrinology Diabetes and Metabolism University of Lausanne Lausanne Switzerland
Division of Endocrinology Ospedale Fazzi Lecce Italy
East Surrey Hospital Surrey and Sussex Healthcare NHS Trust Redhill Surrey United Kingdom
Faculty of Medicine University of Belgrade Belgrade Serbia
Instituto de Investigación Sanitaria de Navarra Pamplona Spain
Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana Majadahonda Madrid Spain
Koru Ankara Hospital Department of Endocrinology and Metabolism Çankaya Ankara Turkey
Medical Faculty University of Coimbra Coimbra Portugal
Rabin Medical Center Tel Aviv University Tel Aviv Israel
Robert Graves Institute Tallaght University Hospital Dublin Ireland
School of Medicine University College Dublin Ireland
Scientific Committee Associazione Medici Endocrinologi Milan Italy
Citace poskytuje Crossref.org
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- $a BACKGROUND: Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. PURPOSE: To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. METHODS: Online survey on the use of TH for growing SG among thyroid experts from 28 European countries. RESULTS: The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41-50, 51-60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03-1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33-0.48), Northern Europe (OR 0.28, 95% CI 0.22-0.36) and Western Asia (OR 0.16, 95% CI 0.11-0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. CONCLUSIONS: Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.
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