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Association between complex exposure to cadmium and mercury and atopic dermatitis in elementary school students: analysis using data from the Korean National Environmental Health Survey (KoNEHS) Cycle 4
K. Baek
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Digitální knihovna NLK
Zdroj
NLK
Free Medical Journals
od 2004
ProQuest Central
od 2009-03-01 do Před 6 měsíci
Medline Complete (EBSCOhost)
od 2006-03-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2009-03-01 do Před 6 měsíci
Public Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
ROAD: Directory of Open Access Scholarly Resources
od 1993
PubMed
40293823
DOI
10.21101/cejph.a8437
Knihovny.cz E-zdroje
- MeSH
- atopická dermatitida * epidemiologie chemicky indukované MeSH
- dítě MeSH
- kadmium * moč škodlivé účinky MeSH
- látky znečišťující životní prostředí * moč MeSH
- lidé MeSH
- prevalence MeSH
- rtuť * moč škodlivé účinky MeSH
- studenti statistika a číselné údaje MeSH
- vystavení vlivu životního prostředí * škodlivé účinky statistika a číselné údaje analýza MeSH
- zdravotnické přehledy MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Korejská republika MeSH
OBJECTIVES: Atopic dermatitis (AD) is a common allergic disease with potential links to environmental pollutants, including heavy metals. This study investigates the association between co-exposure to cadmium and mercury and AD among Korean children. METHODS: Data from the fourth cycle of the Korean National Environmental Health Survey (KoNEHS) included 736 elementary school students. Urinary cadmium and mercury levels were measured, and their association with lifetime prevalence of AD was analysed using logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (QGC), and Bayesian kernel machine regression (BKMR). Confounders adjusted included age, sex, urinary cotinine, income, and body mass index. Sensitivity analyses used symptomatic AD and AD treatment as outcome variables. RESULTS: Among two metals, only cadmium in the highest tertile showed an odds ratio (OR) of 2.39 (95% CI: 1.12-5.10) compared with lowest tertile, with a significant trend per tertile increase (OR 1.58, 95% CI: 1.08-2.31) in multiple logistic regression. Co-exposure analysis using WQS and QGC revealed significant associations with AD prevalence, with WQS showing an OR of 1.47 (95% CI: 1.18-1.83) and QGC showing an OR of 1.60 (95% CI: 1.20-2.13) per tertile increase of exposure. BKMR indicated a dose-dependent relationship between overall exposure and AD risk. For symptomatic AD, similar trend was found. The treatment status of AD did not show a significant association with either heavy metal. CONCLUSION: This study suggests a significant association between co-exposure to cadmium and mercury and atopic dermatitis, emphasizing the need to consider combined environmental exposures in epidemiological studies.
Citace poskytuje Crossref.org
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- $a Baek, Kiook $u Department of Preventive Medicine, College of Medicine, Dongguk University Gyeongju, Gyeongju, Republic of Korea $u Department of Occupational and Environmental Medicine, Dongguk University Gyeongju Hospital, Gyeongju, Republic of Korea $u Department of Medicine, Graduate School of Kyungpook National University, Daegu, Republic of Korea
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