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In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
O. Sokol, AT. Frederiksen, M. Sitarz, BS. Sørensen, E. Santina, C. Smith, JW. Warmenhoven, M. Davídková, AJ. Michaelidesová, I. Danilová, O. Zahradníček, AM. Leite, L. de Marzi, F. Pouzoulet, P. Olko, J. Miszczyk, B. Orzechowska, E. Papalanis, M....
Status neindexováno Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2016
PubMed Central
od 2016
ROAD: Directory of Open Access Scholarly Resources
od 2016
- Publikační typ
- časopisecké články MeSH
BACKGROUND AND PURPOSE: This study presents a multi-center comparison of in vitro cell survival measurements and RBE calculations following proton irradiations conducted under harmonized experimental conditions across six European institutions participating in the INSPIRE framework. MATERIALS AND METHODS: V79-4 cells were irradiated using spread-out Bragg peak (SOBP) proton fields of two configurations delivering 6 and 8 Gy with widths of 6 and 4 cm, respectively. Each center adhered to a standardized protocol, utilizing the same phantom design to minimize uncertainties related to sample positioning. X-ray reference irradiations were also performed to assess cell radiosensitivity across the participating centers. RESULTS: Despite the consistent protocol, significant inter-institutional variability was observed in the survival measurements. For both treatment plans, the largest variation was detected in the most distal points of the SOBP (coefficients of variation of 43 % and 60 % for the 6 Gy and 8 Gy plans, respectively). Kruskal-Wallis statistical test confirmed the significant differences between the centers for each of the measured position in the proton field for both SOBP configurations. Discrepancies were observed in calculated RBE data as well, albeit preserving the expected trend for the values to slightly increase towards the distal edge of the SOBP (up to 1.5 and 1.3 for the 6 Gy and 8 Gy plans, respectively). CONCLUSION: The results of the study highlight the minimal biological variation one could expect performing proton RBE measurements in well-aligned experimental conditions and challenges in conducting large-scale, multi-center radiobiological experiments and inter-comparisons between literature data sets.
CIMAP CEA CNRS ENSICAEN UNICAEN Normandie Université Caen France
Danish Centre for Particle Therapy Aarhus University Hospital Aarhus Denmark
Department of Experimental Clinical Oncology Aarhus University Hospital Aarhus Denmark
Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden
GSI Helmholtz Centre for Heavy Ion Research Darmstadt Germany
Helmholtz Zentrum Dresden Rossendorf Institute of Radiation Physics Dresden Germany
Helmholtz Zentrum Dresden Rossendorf Institute of Radiooncology OncoRay Dresden Germany
Institute for Condensed Matter Physics Technische Universität Darmstadt Darmstadt Germany
Institute of Nuclear Physics Polish Academy of Sciences Krakow Poland
Manchester Academic Health Science Centre The Christie NHS Foundation Trust Manchester UK
Nuclear Physics Institute of the Czech Academy of Sciences Řež Czech Republic
OncoRay National Center for Radiation Research in Oncology Faculty of Medicine Dresden Germany
Citace poskytuje Crossref.org
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