-
Je něco špatně v tomto záznamu ?
The interaction between the expression of CD23 molecule on B- lymphocytes and the level of specific IgE against molecular components of pollen in atopic dermatitis patients with and without dupilumab therapy
J. Čelakovská, E. Čermáková, P. Boudková
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2017
ProQuest Central
od 2020-01-01
Taylor & Francis Open Access
od 2004-01-01
Medline Complete (EBSCOhost)
od 2008-01-01
Health & Medicine (ProQuest)
od 2020-01-01
- MeSH
- alergeny imunologie MeSH
- atopická dermatitida * imunologie farmakoterapie MeSH
- B-lymfocyty * imunologie MeSH
- dospělí MeSH
- humanizované monoklonální protilátky * terapeutické užití MeSH
- imunoglobulin E * krev imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- pyl * imunologie MeSH
- receptory IgE * metabolismus imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The aim of the study here was to evaluate the association between expression of CD23 molecule on B-lymphocytes and the level of specific IgE to molecular components of birch, Bermuda grass, hazel pollen, timothy, and rye grass in atopic dermatitis (AD) patients (with and without dupilumab therapy). A total of 46 patients suffering from AD were included: 26 without dupilumab treatment and 20 with dupilumab treatment. Serum levels of specific IgE were measured by the components resolved diagnostic assay ALEX2 Allergy Xplorer, the expression of CD23 molecule on B-lymphocytes was evaluated with flow cytometry. For the statistical analysis, the Spearman's rank correlation coefficient was used. In patients treated with dupilumab, the higher association was observed between the expression of CD23 on B-lymphocytes and specific IgE to molecular components Bet v 1, Cor a 1.0103, Cor a 1.0401, and Phl p 1. This study demonstrated that the relationship between CD23 expression on B-lymphocytes and specific IgE to pollen molecular components varies depending on whether the patient was treated with dupilumab and the type of molecular component involved.
Department of Medical Biophysics Medical Faculty of Charles University Hradec Králové Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25015078
- 003
- CZ-PrNML
- 005
- 20250731090740.0
- 007
- ta
- 008
- 250708s2025 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/1547691X.2025.2507311 $2 doi
- 035 __
- $a (PubMed)40432597
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Čelakovská, J $u Department of Dermatology and Venereology, Faculty Hospital and Medical, Faculty of Charles University, Hradec Králové, Czech Republic
- 245 14
- $a The interaction between the expression of CD23 molecule on B- lymphocytes and the level of specific IgE against molecular components of pollen in atopic dermatitis patients with and without dupilumab therapy / $c J. Čelakovská, E. Čermáková, P. Boudková
- 520 9_
- $a The aim of the study here was to evaluate the association between expression of CD23 molecule on B-lymphocytes and the level of specific IgE to molecular components of birch, Bermuda grass, hazel pollen, timothy, and rye grass in atopic dermatitis (AD) patients (with and without dupilumab therapy). A total of 46 patients suffering from AD were included: 26 without dupilumab treatment and 20 with dupilumab treatment. Serum levels of specific IgE were measured by the components resolved diagnostic assay ALEX2 Allergy Xplorer, the expression of CD23 molecule on B-lymphocytes was evaluated with flow cytometry. For the statistical analysis, the Spearman's rank correlation coefficient was used. In patients treated with dupilumab, the higher association was observed between the expression of CD23 on B-lymphocytes and specific IgE to molecular components Bet v 1, Cor a 1.0103, Cor a 1.0401, and Phl p 1. This study demonstrated that the relationship between CD23 expression on B-lymphocytes and specific IgE to pollen molecular components varies depending on whether the patient was treated with dupilumab and the type of molecular component involved.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a atopická dermatitida $x imunologie $x farmakoterapie $7 D003876
- 650 12
- $a imunoglobulin E $x krev $x imunologie $7 D007073
- 650 12
- $a receptory IgE $x metabolismus $x imunologie $7 D017455
- 650 12
- $a pyl $x imunologie $7 D011058
- 650 12
- $a humanizované monoklonální protilátky $x terapeutické užití $7 D061067
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a B-lymfocyty $x imunologie $7 D001402
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a alergeny $x imunologie $7 D000485
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a mladiství $7 D000293
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Čermáková, E $u Department of Medical Biophysics, Medical Faculty of Charles University, Hradec Králové, Czech Republic
- 700 1_
- $a Boudková, P $u Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic
- 773 0_
- $w MED00188773 $t Journal of immunotoxicology $x 1547-6901 $g Roč. 22, č. 1 (2025), s. 2507311
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40432597 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250708 $b ABA008
- 991 __
- $a 20250731090735 $b ABA008
- 999 __
- $a ok $b bmc $g 2366144 $s 1252203
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 22 $c 1 $d 2507311 $e 20250528 $i 1547-6901 $m Journal of immunotoxicology $n J Immunotoxicol $x MED00188773
- LZP __
- $a Pubmed-20250708
