Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis

AA. Santos, D. Pires, V. Marques, N. Alesina, E. Herraez, P. Roudnický, PM. Rodrigues, A. Godinho-Santos, AC. Bravo, C. Gouveia, S. Saraiva, L. Correia, R. Crespo, JP. da Silva, M. Cravo, D. Potesil, Z. Zdráhal, JM. Banales, JJG. Marin, J....

. 2025 ; 138 (12) : 703-716. [pub] 20250626

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25015250

Grant support
CEECIND/04663/2017 Fundação para a Ciência e a Tecnologia
GEDII Project Award 2019 Grupo de Estudos da Doença Intestinal Inflamatória
Daniel Alagille Award 2019 European Association for the Study of the Liver
PID 23709 CEITEC Proteomic Core Facility, a part of Czech Infrastructure for Integrative Structural Biology (CIISB), Instruct-CZ Centre of Instruct-ERIC EU consortium funded by Instruct-ERIC
LM2023042 and e-INFRA CZ (ID:90254) Ministry of Education, Youth and Sports CR
PI21/00922 - PI18/01075 Instituto de Salud Carlos III
CPII19/00008 Miguel Servet plus Fondo Europeo de Desarrollo Regional" (FEDER)
PI22/00526 Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain, co-funded by the European Regional Development Fund/European Social Fund, "Investing in your future"
SA113P23 Junta de Castilla Control Leon
PID2022-140210OB-I00 AECC Scientific Foundation (2023/2027). Ministerio de Ciencia e Innovación.

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case-control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25015250
003      
CZ-PrNML
005      
20250731090852.0
007      
ta
008      
250708s2025 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1042/CS20256078 $2 doi
035    __
$a (PubMed)40476597
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Santos, André A $u Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal $1 https://orcid.org/0000000232481051
245    10
$a Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis / $c AA. Santos, D. Pires, V. Marques, N. Alesina, E. Herraez, P. Roudnický, PM. Rodrigues, A. Godinho-Santos, AC. Bravo, C. Gouveia, S. Saraiva, L. Correia, R. Crespo, JP. da Silva, M. Cravo, D. Potesil, Z. Zdráhal, JM. Banales, JJG. Marin, J. Torres, CMP. Rodrigues
520    9_
$a Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case-control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls. Serum bile acid profile, proteomic analysis, and immune-related gene expression in the colon tissue were examined. Colonic tissue from PSC patients exhibited up-regulation of immune regulation and inflammatory signaling mRNA markers, including LGR5, IL-8, CCL2, COX2, TWIST1, and SNAIL. Additionally, PSC patients displayed a distinct proinflammatory serum proteomic signature and moderate elevation of some bile acids, such as glycochenodeoxycholic acid (GCDCA). Co-incubation of human-derived monocytes with GCDCA partially replicated the inflammatory profile observed in PSC. These findings suggest that circulating bile acids modulate the peripheral immune system proinflammatory response, contributing to the unique PSC phenotype.
650    _2
$a lidé $7 D006801
650    12
$a sklerozující cholangitida $x imunologie $x krev $x komplikace $x genetika $7 D015209
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
650    12
$a žlučové kyseliny a soli $x krev $x imunologie $7 D001647
650    _2
$a studie případů a kontrol $7 D016022
650    12
$a idiopatické střevní záněty $x imunologie $x komplikace $x krev $x genetika $7 D015212
650    _2
$a dospělí $7 D000328
650    _2
$a lidé středního věku $7 D008875
650    _2
$a kolon $x metabolismus $x imunologie $7 D003106
650    _2
$a monocyty $x imunologie $x metabolismus $7 D009000
650    _2
$a proteomika $x metody $7 D040901
655    _2
$a časopisecké články $7 D016428
700    1_
$a Pires, David $u CIIS - Centro de Investigação Interdisciplinar em Saúde, Faculdade de Medicina, Universidade Católica Portuguesa, Lisboa, Portugal
700    1_
$a Marques, Vanda $u Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
700    1_
$a Alesina, Nicole $u Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
700    1_
$a Herraez, Elisa $u Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain $u Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain
700    1_
$a Roudnický, Pavel $u Mendel Centre of Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Rodrigues, Pedro M $u Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain $u Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain $u Ikerbasque, Basque Foundation for Science, Bilbao, Spain
700    1_
$a Godinho-Santos, Ana $u Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
700    1_
$a Bravo, Ana Catarina $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal
700    1_
$a Gouveia, Catarina $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal
700    1_
$a Saraiva, Susana $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal
700    1_
$a Correia, Luís $u Division of Gastroenterology, ULS Santa Maria, Lisboa, Portugal
700    1_
$a Crespo, Ricardo $u Division of Gastroenterology, Hospital Lusíadas, Lisboa, Portugal
700    1_
$a da Silva, João Pereira $u Division of Gastroenterology, Hospital Lusíadas, Lisboa, Portugal
700    1_
$a Cravo, Marília $u Division of Gastroenterology, Hospital da Luz, Lisboa, Portugal
700    1_
$a Potesil, David $u Mendel Centre of Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Zdráhal, Zbyněk $u Mendel Centre of Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Banales, Jesus Maria $u Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain $u Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain $u Ikerbasque, Basque Foundation for Science, Bilbao, Spain $u Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain
700    1_
$a Marin, Jose J G $u Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain $u Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain
700    1_
$a Torres, Joana $u Center for the Study of Liver and Gastrointestinal Diseases (CIBERehd), Carlos III National Institute of Health, Madrid, Spain $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal $u Division of Gastroenterology, Hospital da Luz, Lisboa, Portugal
700    1_
$a Rodrigues, Cecília Maria Pereira $u Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
773    0_
$w MED00009494 $t Clinical science (1979) $x 1470-8736 $g Roč. 138, č. 12 (2025), s. 703-716
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40476597 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250708 $b ABA008
991    __
$a 20250731090847 $b ABA008
999    __
$a ok $b bmc $g 2366235 $s 1252375
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 138 $c 12 $d 703-716 $e 20250626 $i 1470-8736 $m Clinical science (1979) $n Clin Sci (Lond) $x MED00009494
GRA    __
$a CEECIND/04663/2017 $p Fundação para a Ciência e a Tecnologia
GRA    __
$a GEDII Project Award 2019 $p Grupo de Estudos da Doença Intestinal Inflamatória
GRA    __
$a Daniel Alagille Award 2019 $p European Association for the Study of the Liver
GRA    __
$a PID 23709 $p CEITEC Proteomic Core Facility, a part of Czech Infrastructure for Integrative Structural Biology (CIISB), Instruct-CZ Centre of Instruct-ERIC EU consortium funded by Instruct-ERIC
GRA    __
$a LM2023042 and e-INFRA CZ (ID:90254) $p Ministry of Education, Youth and Sports CR
GRA    __
$a PI21/00922 - PI18/01075 $p Instituto de Salud Carlos III
GRA    __
$a CPII19/00008 $p Miguel Servet plus Fondo Europeo de Desarrollo Regional" (FEDER)
GRA    __
$a PI22/00526 $p Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain, co-funded by the European Regional Development Fund/European Social Fund, "Investing in your future"
GRA    __
$a SA113P23 $p Junta de Castilla Control Leon
GRA    __
$a PID2022-140210OB-I00 $p AECC Scientific Foundation (2023/2027). Ministerio de Ciencia e Innovación.
LZP    __
$a Pubmed-20250708

Find record

Citation metrics

Archiving options